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Drug Repurposing-Based Brain-Targeting Self-Assembly Nanoplatform Using Enhanced Ferroptosis against Glioblastoma

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机构： [1]Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, 570100, China. [2]Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, 570100, China. [3]Department of Anorectal Surgery, Hospital of Chengdu University of Traditional Chinese Medicine and Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China. [4]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China. [5]Department of Oncology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China. [6]Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia. [7]Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Army Military Medical University, Chongqing, 400038, China. [8]School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, 434000, China.

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关键词： blood–brain barriers chemophototherapy drug repurposing ferroptosis glioblastoma multiforme

摘要：

Glioblastoma (GBM), the most aggressive and lethal form of malignant brain tumor, is a therapeutic challenge due to the drug filtration capabilities of the blood-brain barrier (BBB). Interestingly, glioblastoma tends to resist apoptosis during chemotherapy, but is susceptible to ferroptosis. Developing therapies that can effectively target glioblastoma by crossing the BBB and evoke ferroptosis are, therefore, crucial for improving treatment outcomes. Herein, a versatile biomimetic nanoplatform, L-D-I/NPs, is designed that self-assembled by loading the antimalarial drug dihydroartemisinin (DHA) and the photosensitizer indocyanine green (ICG) onto lactoferrin (LF). This nanoplatform can selectively target glioblastoma by binding to low-density lipoprotein receptor-related protein-1 (LRP1) and crossing the BBB, thus inducing glioblastoma cell ferroptosis by boosting intracellular reactive oxygen species (ROS) accumulation and iron overload. In addition, L-D-I/NPs have demonstrated the ability to effectively suppress the progression of orthotopic glioblastoma and significantly prolong survival in a mouse glioblastoma model. This nanoplatform has facilitated the application of non-chemotherapeutic drugs in tumor treatment with minimal adverse effects, paving the way for highly efficient ferroptosis-based therapies for glioblastoma.© 2023 Wiley-VCH GmbH.

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出版当年[2023]版：

大类 | 2 区

材料科学

小类 | 1 区物理：应用 2 区化学：综合 2 区物理化学 2 区材料科学：综合 2 区纳米科技 2 区物理：凝聚态物理

最新[2023]版：

大类 | 2 区

材料科学

小类 | 1 区物理：应用 2 区化学：综合 2 区物理化学 2 区材料科学：综合 2 区纳米科技 2 区物理：凝聚态物理

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出版当年[2023]版：

Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY Q1 PHYSICS, APPLIED Q1 CHEMISTRY, PHYSICAL Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 PHYSICS, CONDENSED MATTER

最新[2023]版：

Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY Q1 PHYSICS, APPLIED Q1 CHEMISTRY, PHYSICAL Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 PHYSICS, CONDENSED MATTER

影响因子： 13 最新[2023版] 13.5 最新五年平均 13 出版当年[2023版] 13.5 出版当年五年平均 13.3 出版前一年[2022版]

第一作者：

第一作者机构： [1]Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, 570100, China. [2]Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, 570100, China.

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通讯作者：

通讯机构： [1]Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, 570100, China. [2]Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, 570100, China.

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Drug Repurposing-Based Brain-Targeting Self-Assembly Nanoplatform Using Enhanced Ferroptosis against Glioblastoma

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