个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Drug Repurposing-Based Brain-Targeting Self-Assembly Nanoplatform Using Enhanced Ferroptosis against Glioblastoma

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Liang Jiantang[1,2] ; Li Lei[3] ; Tian Hailong[4] ; Wang Zhihan[4] ; Liu Guowen[4] ; Duan Xirui[5] ; Guo Meiwen[1,2] ; Liu Jiaqi[1,2] ; Zhang Wei[4] ; Nice Edouard C[6] ; Huang Canhua[4] ; He Weifeng[7] ; Zhang Haiyuan[8] ; Li Qifu[1,2] ;
机构： [1]Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, 570100, China. [2]Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, 570100, China. [3]Department of Anorectal Surgery, Hospital of Chengdu University of Traditional Chinese Medicine and Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, China. [4]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, China. [5]Department of Oncology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China. [6]Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia. [7]Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Army Military Medical University, Chongqing, 400038, China. [8]School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, 434000, China.
出处：
DOI： 10.1002/smll.202303073
ISSN：

关键词： blood–brain barriers chemophototherapy drug repurposing ferroptosis glioblastoma multiforme

摘要：
Glioblastoma (GBM), the most aggressive and lethal form of malignant brain tumor, is a therapeutic challenge due to the drug filtration capabilities of the blood-brain barrier (BBB). Interestingly, glioblastoma tends to resist apoptosis during chemotherapy, but is susceptible to ferroptosis. Developing therapies that can effectively target glioblastoma by crossing the BBB and evoke ferroptosis are, therefore, crucial for improving treatment outcomes. Herein, a versatile biomimetic nanoplatform, L-D-I/NPs, is designed that self-assembled by loading the antimalarial drug dihydroartemisinin (DHA) and the photosensitizer indocyanine green (ICG) onto lactoferrin (LF). This nanoplatform can selectively target glioblastoma by binding to low-density lipoprotein receptor-related protein-1 (LRP1) and crossing the BBB, thus inducing glioblastoma cell ferroptosis by boosting intracellular reactive oxygen species (ROS) accumulation and iron overload. In addition, L-D-I/NPs have demonstrated the ability to effectively suppress the progression of orthotopic glioblastoma and significantly prolong survival in a mouse glioblastoma model. This nanoplatform has facilitated the application of non-chemotherapeutic drugs in tumor treatment with minimal adverse effects, paving the way for highly efficient ferroptosis-based therapies for glioblastoma.© 2023 Wiley-VCH GmbH.

基金：
This work was supported by grants from the National Natural Science Foundation of China (82200592, 81960249, 82260270, and 81821002), 1.3.5 project for disciplines of excellence (ZYGD22007, ZYJC21004), Hainan Province Science and Technology Special Fund (ZDYF2022SHFZ109), Hainan Province Clinical Medical Center (2021), Epilepsy Research Science Innovation Group of Hainan Medical University (2022), The Excellent Talent Team of Hainan Province (No. QRCBT202121).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 材料科学
小类 | 1 区 物理：应用 2 区 化学：综合 2 区 物理化学 2 区 材料科学：综合 2 区 纳米科技 2 区 物理：凝聚态物理
最新[2023]版：
大类 | 2 区 材料科学
小类 | 1 区 物理：应用 2 区 化学：综合 2 区 物理化学 2 区 材料科学：综合 2 区 纳米科技 2 区 物理：凝聚态物理
JCR分区：
出版当年[2023]版：
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 CHEMISTRY, PHYSICAL Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY Q1 PHYSICS, APPLIED Q1 PHYSICS, CONDENSED MATTER
最新[2023]版：
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 CHEMISTRY, PHYSICAL Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY Q1 PHYSICS, APPLIED Q1 PHYSICS, CONDENSED MATTER

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, 570100, China. [2]Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, 570100, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, 570100, China. [2]Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, 570100, China.
推荐引用方式(GB/T 7714)：
Liang Jiantang,Li Lei,Tian Hailong,et al.Drug Repurposing-Based Brain-Targeting Self-Assembly Nanoplatform Using Enhanced Ferroptosis against Glioblastoma[J].SMALL.2023,19(46):doi:10.1002/smll.202303073.
APA：
Liang Jiantang,Li Lei,Tian Hailong,Wang Zhihan,Liu Guowen...&Li Qifu.(2023).Drug Repurposing-Based Brain-Targeting Self-Assembly Nanoplatform Using Enhanced Ferroptosis against Glioblastoma.SMALL,19,(46)
MLA：
Liang Jiantang,et al."Drug Repurposing-Based Brain-Targeting Self-Assembly Nanoplatform Using Enhanced Ferroptosis against Glioblastoma".SMALL 19..46(2023)

相关文献

[1]Treatments against Polymorphosal discrepancies in Glioblastoma Multiforme [2]Overcoming cancer therapeutic bottleneck by drug repurposing. [3]Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development [4]Identifying A Radiomics Imaging Signature for Prediction of Overall Survival in Glioblastoma Multiforme [5]Automatic extraction of MRI radiomics features in glioblastoma multiforme: A reproducibility evaluation [6]Automatic Extraction of MRI Radiomics Features in Glioblastoma Multiforme: A Reproducibility Evaluation [7]The comparison genomics analysis with glioblastoma multiforme (GBM) cells under 3D and 2D cell culture conditions. [8]Guideline conformity to the Stupp regimen in patients with newly diagnosed glioblastoma multiforme in China [9]THE ELEVATED PRETREATMENT ASPARTATE AMINOTRANSFERASE TO LYMPHOCYTE RATIO INDEX PREDICTS POOR PROGNOSIS IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA MULTIFORME [10]Identifying a radiomics imaging signature for prediction of overall survival in glioblastoma multiforme

资源点击量：43377 今日访问量：0 总访问量：3120 更新日期：2024-09-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 四川省肿瘤医院 技术支持：重庆聚合科技有限公司 地址：成都市人民南路四段55号