详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation.

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]College of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China [2]National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China [3]Tsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China [4]State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China [5]School of Medicine, Tsinghua University, Beijing 100084, China [6]Collaborative Innovation Center for Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China

出处：

DOI：

ISSN：

关键词： Enterovirus 71 NITD008 Nucleoside analogue Polymerase

摘要：

Enterovirus 71 (EV71), one of the major causative agents of Hand-Foot-Mouth Disease (HFMD), causes severe pandemics and hundreds of deaths in the Asia-Pacific region annually and is an enormous public health threat. However, effective therapeutic antiviral drugs against EV71 are rare. Nucleoside analogues have been successfully used in the clinic for the treatment of various viral infections. We evaluated a total of 27 nucleoside analogues and discovered that an adenosine nucleoside analogue NITD008, which has been reported to be an antiviral reagent that specifically inhibits flaviviruses, effectively suppressed the propagation of different strains of EV71 in RD, 293T and Vero cells with a relatively high selectivity index. Triphosphorylated NITD008 (ppp-NITD008) functions as a chain terminator to directly inhibit the RNA-dependent RNA polymerase activity of EV71, and it does not affect the EV71 VPg uridylylation process. A significant synergistic anti-EV71 effect of NITD008 with rupintrivir (AG7088) (a protease inhibitor) was documented, supporting the potential combination therapy of NITD008 with other inhibitors for the treatment of EV71 infections. Copyright © 2014 Elsevier B.V. All rights reserved.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2014]版：

大类 | 2 区医学

小类 | 2 区药学 3 区病毒学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区药学 2 区病毒学

第一作者：

第一作者机构： [1]College of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

共同第一作者：

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Studies on Inhibition of Proliferation of Enterovirus-71 by Compound YZ-LY-0. [2]Cyclophilin A associates with enterovirus-71 virus capsid and plays an essential role in viral infection as an uncoating regulator. [3]Oblongifolin M, an active compound isolated from a Chinese medical herb Garcinia oblongifolia, potently inhibits enterovirus 71 reproduction through downregulation of ERp57. [4]Mitochondrial DNA D-loop AG/TC transition mutation in cortical neurons of mice after long-term exposure to nucleoside analogues. [5]DNA polymerase delta governs parental histone transfer to DNA replication lagging strand [6]Programmable endonuclease combined with isothermal polymerase amplification to selectively enrich for rare mutant allele fractions [7]Cockayne Syndrome Linked to Elevated R-Loops Induced by Stalled RNA Polymerase II during Transcription Elongation [8]Selection of reference genes for gene expression studies in human bladder cancer using SYBR-Green quantitative polymerase chain reaction [9]BP[dG]-induced distortions to DNA polymerase and DNA duplex: A detailed mechanism of BP adducts blocking replication. [10]190P Real world applications of poly (ADP-ribose) polymerase inhibitors for ovarian cancer: a single-center study in China