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Antibiotic drug tigecycline inhibited cell proliferation and induced autophagy in gastric cancer cells.

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机构： [1]State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, PR China [2]Division of Scientific Research and Training, General Hospital of PLA Chengdu Military Area Command, Chengdu, Sichuan 610083, PR China [3]Institute of Urinary Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, PR China

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关键词： Tigecycline Gastric cancer Proliferation inhibition Autophagy

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Tigecycline acts as a glycylcycline class bacteriostatic agent, and actively resists a series of bacteria, specifically drug fast bacteria. However, accumulating evidence showed that tetracycline and their derivatives such as doxycycline and minocycline have anti-cancer properties, which are out of their broader antimicrobial activity. We found that tigecycline dramatically inhibited gastric cancer cell proliferation and provided an evidence that tigecycline induced autophagy but not apoptosis in human gastric cancer cells. Further experiments demonstrated that AMPK pathway was activated accompanied with the suppression of its downstream targets including mTOR and p70S6K, and ultimately induced cell autophagy and inhibited cell growth. So our data suggested that tigecycline might act as a candidate agent for pre-clinical evaluation in treatment of patients suffering from gastric cancer. Copyright © 2014 Elsevier Inc. All rights reserved.

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出版当年[2014]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学 4 区生物物理

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学

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第一作者机构： [1]State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, PR China

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通讯机构： [1]State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, PR China [*1]State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, 216, Tiansheng Rd., Beibei District, Chongqing 400716, PR China

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