机构：[1]State Key Laboratory of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China四川大学华西医院[2]College of Life Sciences, Sichuan University, Chengdu 610064, China[3]Analytical & Testing Center, Sichuan University, Chengdu 610064, China[4]Department of Pharmacology and The Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA[5]School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Sirtuin-3 (SIRT3), a major mitochondria NAD+-dependent deacetylase, may target mitochondrial proteins for lysine deacetylation and also regulate cellular functions. And, SIRT3 is an emerging instrumental regulator of the mitochondrial adaptive response to stress, such as metabolic reprogramming and antioxidant defense mechanisms. Accumulating evidence has recently demonstrated that SIRT3 may function as either oncogene or tumor suppressor on influencing cell death by targeting a series of key modulators and their relevant pathways in cancer. Thus, in this review, we present the structure, transcriptional regulation, and posttranslational modifications of SIRT3. Subsequently, we focus on highlighting the Janus role of SIRT3 with oncogenic or tumor-suppressive function in cancer, which may provide more new clues for exploring SIRT3 as a therapeutic target for drug discovery.
基金：
This work was supported by grants from the
National 973 Basic Research Program of China (Nos. 2010CB529900 and
2013CB911300), the Key Projects of the National Science and Technology Pillar
Program (No. 2012BAI30B02), National Natural Science Foundation of China
(Nos. U1170302, 81260628, 81303270 and 81202403), Shenyang Science and
Technology Project (No. F12-157-9-00), Shenyang Pharmaceutical University
scientific research fund (No. ZCJJ2013407) and Autonomous Region of Xinjiang
Project of Science and Technology (No. 201191259)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|2 区生物
小类|3 区细胞生物学
最新[2023]版：
大类|1 区生物学
小类|2 区细胞生物学
第一作者：
第一作者机构：[1]State Key Laboratory of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China[4]Department of Pharmacology and The Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA[5]School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China[*1]State Key Laboratory of Biotherapy, Sichuan University, Ke-yuan Road 4, No 1, Gao-peng Street, Chengdu, Sichuan 610041, China
推荐引用方式(GB/T 7714)：
Chen Y,Fu L L,Wen X,et al.Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer.[J].Cell death & disease.2014,5:e1047.doi:10.1038/cddis.2014.14.
APA：
Chen Y,Fu L L,Wen X,Wang X Y,Liu J...&Huang J.(2014).Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer..Cell death & disease,5,
MLA：
Chen Y,et al."Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer.".Cell death & disease 5.(2014):e1047
生物学