机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, P.R. China.四川大学华西医院[2]Department of Urinary Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.四川大学华西医院[3]Laboratory of Cell and Molecular Biology and State Key Laboratory of Molecular Oncology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China.
DEAD-box RNA helicase 3 (DDX3) is a highly conserved family member of DEAD-box proteins in all eukaryotes from yeasts to human beings. Accumulating studies have confirmed DDX3 has the ability to regulate different steps of RNA metabolism, including RNA splicing, RNA export, transcription and translation initiation. Moreover, DDX3 is involved in many biological processes, such as stress response, cell apoptosis, cell cycle regulation and virus infection. In recent years, DDX3 is getting increasing attention due to its essential roles in cancer progression. However, DDX3 role in cancer development is rather complicated. This review mainly focuses on the dual roles of DDX3 and DDX3-mediated signaling pathways in multiple cancers. In addition, the interplaying causes for the controversial roles of DDX3 in cancer are discussed. So far several small molecular chemical compounds targeting DDX3 are also summarized from the anticancer activity to the clinical trials of DDX3 inhibitors.
基金：
National Key Basic Research Program of China (grant
nos. 2013CB911303 and 2011CB910703), the National Natural
Sciences Foundation of China (grant no. 31470810), the Science
and Technology Department of Sichuan Province (grant
no. 2017JY0232), the Health and Family Planning Commission
of Sichuan Province (grant no. 17ZD045) and the Guangdong
Innovative Research Team Program (grant no. 2011Y073).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|4 区肿瘤学
最新[2023]版：
大类|3 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, P.R. China.
通讯作者：
通讯机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, P.R. China.[*1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, 17 Section 3, People's South Road, Chengdu, Sichuan 610041, P.R. China
推荐引用方式(GB/T 7714)：
He Yu,Zhang Dan,Yang Yanfang,et al.A double-edged function of DDX3, as an oncogene or tumor suppressor, in cancer progression (Review).[J].Oncology reports.2018,39(3):883-892.doi:10.3892/or.2018.6203.
APA：
He Yu,Zhang Dan,Yang Yanfang,Wang Xixi,Zhao Xinyu...&Liang Shufang.(2018).A double-edged function of DDX3, as an oncogene or tumor suppressor, in cancer progression (Review)..Oncology reports,39,(3)
MLA：
He Yu,et al."A double-edged function of DDX3, as an oncogene or tumor suppressor, in cancer progression (Review).".Oncology reports 39..3(2018):883-892
