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Polybrominated diphenyl ethers (PBDEs) in human samples of mother-newborn pairs in South China and their placental transfer characteristics.

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收录情况： ◇ SCIE

作者：
Chen Zhuo-Jia[1] ; Liu Han-Yan[3] ; Cheng Zhang[4] ; Man Yu-Bon[5,6] ; Zhang Kun-Shui[7] ; Wei Wei[2] ; Du Jun[2] ; Wong Ming-Hung[5,6] ; Wang Hong-Sheng[2,6] ;
机构： [1]Department of Pharmacy, Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China [2]Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, No. 132 Waihuandong Road, University Town, Guangzhou 510006, China [3]Center for Reproductive Medicine, Third Affiliated Hospital of Guangzhou Medical University, Key Laboratory for Major Obstetric Diseases of Guangdong Province, Guangzhou 510150, China [4]College of Resources and Environment, Sichuan Agricultural University, Sichuan 61130, China [5]Consortium on Health, Environment, Education and Research (CHEER), and Department of Science and Environmental Studies, Hong Kong Institute of Education, Tai Po, Hong Kong P.R. China [6]State Key Laboratory in Marine Pollution – Croucher Institute for Environmental Sciences, Hong Kong Baptist University and City University of Hong Kong, Hong Kong, China [7]Department of Pharmacy, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China
出处：
DOI： 10.1016/j.envint.2014.07.002
ISSN：

关键词： PBDEs Human tissues Paired samples Body accumulation Newborns

摘要：
There are limited data concerning the placenta transfer characteristics and accumulation of polybrominated diphenyl ethers (PBDEs) in infants. However, PBDEs received increasing health concerns due to their endocrine disrupt and neurodevelopment toxicity effects. The present study assessed the accumulation of PBDEs in 30 paired placenta, breast milk, fetal cord blood, and neonatal urine samples collected from five major cities of the South China. The age of mothers ranged from 21 to 39 (mean 27.6±4.56). The ∑PBDE concentrations were 15.8±9.88 ng g(-1) lipid in placenta, 13.2±7.64 ng g(-1) lipid in breast milk, 16.5±19.5 ng g(-1) lipid in fetal cord blood, and 1.80±1.99 ng ml(-1) in neonatal urine. BDE-47 was the predominant congener in all types of human sample. Octa-BDEs such as BDE-196/-197 were detected highly in placenta and cord blood while moderately in breast milk and neonatal urine. Significant (p<0.01) correlations were observed for both total and most individual PBDEs in cord blood-maternal placenta and breast milk-urine paired individual samples. The extent of placental transfer of higher brominated BDEs such as BDE-196/-197 was greater than that of BDE-47. The estimated daily intake (EDI) analysis for breast-fed infants revealed that newborns in these areas were exposed to relatively high levels of PBDEs via breast milk. Our study not only provided systematic fundamental data for PBDE distribution but also revealed the placenta transfer characteristics of PBDE congeners in South China. Copyright © 2014 Elsevier Ltd. All rights reserved.

基金：
the National Natural Science Foundation of China (Grant Nos. 81302317 and 31101071), the Seed Collaborative Research Fund from the State Key Laboratory in Marine Pollution (No. SCRF0003), the Fundamental Research Funds for the Central Universities (Sun Yat-sen University) (No. 12ykpy09), the Opening Project of Guangdong Provincial Key Laboratory of New Drug Design and Evaluation (No. 2011A060901014-007), and the Science and Technology Planning Project of Guangdong Province, China (No. 2012B031500005).
语种：
外文
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中科院(CAS)分区：
出版当年[2014]版：
大类 | 1 区 环境科学与生态学
小类 | 1 区 环境科学
最新[2023]版：
大类 | 1 区 环境科学与生态学
小类 | 1 区 环境科学
JCR分区：
出版当年[2014]版：
Q1 ENVIRONMENTAL SCIENCES
最新[2023]版：
Q1 ENVIRONMENTAL SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

第一作者：
第一作者机构： [1]Department of Pharmacy, Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
共同第一作者：
通讯作者：
通讯机构： [2]Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, No. 132 Waihuandong Road, University Town, Guangzhou 510006, China [5]Consortium on Health, Environment, Education and Research (CHEER), and Department of Science and Environmental Studies, Hong Kong Institute of Education, Tai Po, Hong Kong P.R. China [6]State Key Laboratory in Marine Pollution – Croucher Institute for Environmental Sciences, Hong Kong Baptist University and City University of Hong Kong, Hong Kong, China
推荐引用方式(GB/T 7714)：
Chen Zhuo-Jia,Liu Han-Yan,Cheng Zhang,et al.Polybrominated diphenyl ethers (PBDEs) in human samples of mother-newborn pairs in South China and their placental transfer characteristics.[J].ENVIRONMENT INTERNATIONAL.2014,73:77-84.doi:10.1016/j.envint.2014.07.002.
APA：
Chen Zhuo-Jia,Liu Han-Yan,Cheng Zhang,Man Yu-Bon,Zhang Kun-Shui...&Wang Hong-Sheng.(2014).Polybrominated diphenyl ethers (PBDEs) in human samples of mother-newborn pairs in South China and their placental transfer characteristics..ENVIRONMENT INTERNATIONAL,73,
MLA：
Chen Zhuo-Jia,et al."Polybrominated diphenyl ethers (PBDEs) in human samples of mother-newborn pairs in South China and their placental transfer characteristics.".ENVIRONMENT INTERNATIONAL 73.(2014):77-84

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