Effects of titanium dioxide nanoparticles coupled with diode laser on optical properties of in vitro normal and cancerous human lung tissues studied with optical coherence tomography and diffuse reflectance spectra.
机构：[a]South China Normal University, College of Biophotonics, MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, 55 Zhongshan Road, Guangzhou, Guangdong Province 510631, China[b]Sun Yat-Sen University, the First Affiliated Hospital, Department of Surgery, 58 Zhongshan 2 Road, Guangzhou, Guangdong Province 510080, China中山大学附属第一医院[c]Fujian Normal University, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education of China, 1 Keji Road, Fuzhou, Fujian 350007, China[d]Tsinghua University, Graduate School at Shenzhen, 2279 Lishui Road, Shenzhen, Guangdong 518055, China[e]Southwest Institute of Technical Physics, 7 People’s South Road, Chengdu, Sichuan 610041, China
The objective is to investigate the effects of two different sized (60 and 100 nm) titanium dioxide (TiO2) nanoparticles (NPs) penetration and accumulation in in vitro human normal lung (NL) tissue, lung squamous cell carcinoma (LSCC) tissue, and 650-nm diode laser-pretreated tissue on their optical properties studied with optical coherence tomography monitoring and diffuse reflectance (DR) spectra measurement. As with TiO2 NPs penetrating into the tissues, the intensities of DR of the samples increase, and then the enhancements of DR and the attenuation coefficients of the tissues were quantitatively calculated. The results suggest that 650-nm diode laser pretreatment increased the amounts of TiO2 NPs penetration and accumulation in NL and LSCC tissues, and the tissue optical properties were significantly influenced by accumulation of TiO2 NPs.
基金：
This work was supported by the National Natural Science
Foundation of China (Grant Nos. 60778047, 61335011,
61275187, and 81071790), Specialized Research Fund for
the Doctoral Program of Higher Education of China (Grant
Nos. 20114407110001 and 200805740003), the Science and
Technology Innovation Project of the Education Department of
Guangdong Province of China, the Natural Science Foundation
of Guangdong Province of China (Grant Nos. 06025080
and 9251063101000009), Technique invention program of
Guangdong Province (2013KJCX0052), the Science and
Technology Project of Guangdong Province (2012A080203008),
and Key Laboratory of Optoelectronic Science and Technology
for Medicine (Fujian Normal University), Ministry of Education,
China (Grant No. JYG1202).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|3 区医学
小类|2 区光学3 区生化研究方法3 区核医学
最新[2023]版：
大类|3 区医学
小类|2 区生化研究方法3 区光学3 区核医学
JCR分区：
出版当年[2015]版：
Q1OPTICSQ2BIOCHEMICAL RESEARCH METHODSQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q2BIOCHEMICAL RESEARCH METHODSQ2OPTICSQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[a]South China Normal University, College of Biophotonics, MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, 55 Zhongshan Road, Guangzhou, Guangdong Province 510631, China
通讯作者：
推荐引用方式(GB/T 7714)：
Lianpeng Zhou,Guoyong Wu,Huajiang Wei,et al.Effects of titanium dioxide nanoparticles coupled with diode laser on optical properties of in vitro normal and cancerous human lung tissues studied with optical coherence tomography and diffuse reflectance spectra.[J].JOURNAL OF BIOMEDICAL OPTICS.2015,20(4):doi:10.1117/1.JBO.20.4.046003.
APA：
Lianpeng Zhou,Guoyong Wu,Huajiang Wei,Zhouyi Guo,Hongqin Yang...&Qingan Meng.(2015).Effects of titanium dioxide nanoparticles coupled with diode laser on optical properties of in vitro normal and cancerous human lung tissues studied with optical coherence tomography and diffuse reflectance spectra..JOURNAL OF BIOMEDICAL OPTICS,20,(4)
MLA：
Lianpeng Zhou,et al."Effects of titanium dioxide nanoparticles coupled with diode laser on optical properties of in vitro normal and cancerous human lung tissues studied with optical coherence tomography and diffuse reflectance spectra.".JOURNAL OF BIOMEDICAL OPTICS 20..4(2015)
