机构:[1]Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China.江苏省人民医院[2]Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.江苏省人民医院[3]College of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, China.[4]Institute of Dermatology Surgery, China Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu, China.[5]Department of Dermatology, Shanghai Skin Diseases Hospital, Shanghai, China.[6]Department of Urology, Jiangsu Province Official Hospital, Nanjing, Jiangsu, China.[7]State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, China.
Delayed first medical consultation (patient's delay) is quite common in cases of penile carcinoma (PC), but its reasons and impacts remain unclear. We conducted this study to ascertain risk factors resulting in delayed treatment seeking and evaluate its influence on prognosis.
From 2004 to 2010 at 4 centers, 254 patients were enrolled into this study from 262 consecutive PC cases. Patients' sexual performance was investigated using the International Index of Erectile Function (IIEF)-15 at the sixth-month end after treatment. Data for prognostic analyses was obtained via a 5-year follow-up.
A multivariate model ascertained 4 risk factors (single, living in rural areas, heavy drinking alcohol, and aspecific initial symptoms) and 1 protective factor (history of condyloma) significantly associated with patient's delay. Delay >3 months led to significant risks for adverse clinical characteristics, low penis-sparing rate, and poor sexual function restoration. Although patient's delay was not found to impact on postoperative relapses and 5-year overall survival (OS), patients with delay >6 months had significantly inferior 2-year OS.
Single, living in rural areas, heavy drinking alcohol, and aspecific initial symptoms are significant risk factors of PC associated with patient's delay. Delay >3 months will lead to significantly inferior clinical consequences. Minimizing patient's delay is the key to avoid amputation and retain superior sexual potency. Improving patient education on initial symptoms of PC is necessary in men of >40 years old.
第一作者机构:[2]Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
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推荐引用方式(GB/T 7714):
Wen Gao,Le-bin Song,Jie Yang,et al.Risk factors and negative consequences of patient's delay for penile carcinoma.[J].WORLD JOURNAL OF SURGICAL ONCOLOGY.2016,14:-.doi:10.1186/s12957-016-0863-z.
APA:
Wen Gao,Le-bin Song,Jie Yang,Ning-hong Song,Xin-feng Wu...&Zeng-jun Wang.(2016).Risk factors and negative consequences of patient's delay for penile carcinoma..WORLD JOURNAL OF SURGICAL ONCOLOGY,14,
MLA:
Wen Gao,et al."Risk factors and negative consequences of patient's delay for penile carcinoma.".WORLD JOURNAL OF SURGICAL ONCOLOGY 14.(2016):-