机构：[1]State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No. 14, Sec.3, Renminnan Road, Chengdu, Sichuan 610041, China.[2]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.四川大学华西医院[3]Guangdong Provincial Key Laboratory of Oral Diseases, Stomatological Hospital, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, China.[4]Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou, China
Despite recent advances in oral squamous cell carcinoma (OSCC) diagnosis and therapy, disease recurrence remains common and is strongly associated with mortality. It is therefore critical to identify new targets for both treatment and diagnostic purposes. We aimed at investigating the role of PA28α, a proteasomal activator in OSCC.
The expression of PA28α was examined in a panel of OSCC cell lines and tissues, associated with oncomine analysis. In a large OSCC patient cohort, the prognostic value of PA28α expression was evaluated. Primary clinical end points were recurrence-free and overall survival rate. Functional involvement of PA28α in OSCC was examined in both in vitro and in vivo models upon specific siRNA knockdown.
PA28α was found to be overexpressed in OSCC cell lines and tumor tissues. High expression of PA28α was significantly associated with recurrence and poorer overall survival. Specific knockdown of PA28α inhibited OSCC cell proliferation, migration, invasion in vitro and reduced the growth of OSCC xenografts in vivo. Multivariate Cox regression analyses revealed PA28α as independent prognostic predictors.
These results suggest that PA28α is involved in OSCC oncogenesis and may serve as a potential prognostic factor.
基金：
This project was supported by Foundation for Innovative Research Groups of
the National Natural Science Foundation of China (81520108009); the National
Natural Science Foundations of China (No. 81472533, 81272954, 81472524,81402230, 81372890)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类|2 区医学
小类|3 区肿瘤学
最新[2023]版：
大类|1 区医学
小类|2 区肿瘤学
第一作者：
第一作者机构：[1]State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No. 14, Sec.3, Renminnan Road, Chengdu, Sichuan 610041, China.
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No. 14, Sec.3, Renminnan Road, Chengdu, Sichuan 610041, China.[3]Guangdong Provincial Key Laboratory of Oral Diseases, Stomatological Hospital, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, China.
推荐引用方式(GB/T 7714)：
Xiaodong Feng,Yuchen Jiang,Liang Xie,et al.Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma.[J].Journal of experimental & clinical cancer research : CR.2016,35:35.doi:10.1186/s13046-016-0309-z.
APA：
Xiaodong Feng,Yuchen Jiang,Liang Xie,Lu Jiang,Jing Li...&Qianming Chen.(2016).Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma..Journal of experimental & clinical cancer research : CR,35,
MLA：
Xiaodong Feng,et al."Overexpression of proteasomal activator PA28α serves as a prognostic factor in oral squamous cell carcinoma.".Journal of experimental & clinical cancer research : CR 35.(2016):35
医学