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NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.

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收录情况： ◇ SCIE

作者：
Li Wan-Yu[a] * ; Zhou Hong-Zhong[a] * ; Chen Yao[b] * ; Cai Xue-Fei[a] ; Tang Hua[a] ; Ren Ji-Hua[a] ; Wai Wong Vincent Kam[c] ; Kwan Law Betty Yuen[c] ; Chen Yong[d] ; Cheng Sheng-Tao[a] ; Yu Hai-Bo[a] ; Cai Hao-Yang[e] ; Chen Wei-Xian[f] ; Tang Ni[a] ; Zhang Wen-Lu[a] ; Tao Na-Na[a] ; Yang Qiu-Xia[a] ; Ren Fang[a] ; He Lin[a] ; Jiang Hui[a] ; Huang Ai-Long[a,*1] ; Chen Juan[a,*1] ;
机构： [a]The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China [b]Medical Examination Center, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China [c]State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China [d]Department of Hepatobliliary Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing, China [e]Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resources and Eco-Environment, College of Life Sciences, Sichuan University, Chengdu, China [f]Department of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
出处：
DOI： 10.1016/j.canlet.2019.02.053
ISSN：

关键词： NQO1 Hepatocellular carcinoma X-linked inhibitor of apoptosis protein Apoptosis

摘要：
NAD(P)H: quinone oxidoreductase 1 (NQO1) is an antioxidant enzyme which is associated with poor prognosis in human breast, colon, lung and liver cancers. However, the molecular mechanisms underlying the pro-tumorigenic function of NQO1 remains unclear. This study investigated the function of NQO1 in the context of hepatocellular carcinoma (HCC) development. We found that NQO1 was frequently up-regulated in human liver cancer, and its high expression level was correlated with the tumor stage and low survival rate of HCC patients. Loss-of-function of NQO1 inhibited growth in HCC cells with increased apoptosis in vitro, and suppressed orthotopic tumorigenicity in vivo. Mechanistically, high level of NQO1 in HCC cells enhanced protein stability of X-linked inhibitor of apoptosis protein (XIAP) by increasing its phosphorylation at Ser 87. Reintroduction of wile type XIAP and the phospho-mimic mutants XIAPS87D significantly reversed NQO1 knock-down/out induced growth inhibition and apoptosis. In mouse model with orthotopically implanted hepatocarcinoma, NQO1 suppression and NQO1 inhibitor suppressed tumor growth and induced apoptosis. NQO1 plays an important role in sustaining HCC cell proliferation and may thus act as a potential therapeutic target in HCC treatment. Copyright © 2019 Elsevier B.V. All rights reserved.

基金：
National Natural Science Foundation of China (81672012, JC), National Science and Technology Major Project (2017ZX10202203, ALH), Chongqing Natural Science Foundation (cstc2016jcyjA0183, JC) and the Leading Talent Program of CQ CSTC (CSTCCXLJRC201719, NT).
语种：
外文
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WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学
最新[2023]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
JCR分区：
出版当年[2019]版：
Q1 ONCOLOGY
最新[2023]版：
Q1 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [a]The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
共同第一作者：
通讯作者：
通讯机构： [a]The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China [*1]Room 617, College of Life Sciences Building, 1 YiXueYuan Road, YuZhong District, Chongqing, 400016, China.
推荐引用方式(GB/T 7714)：
Li Wan-Yu,Zhou Hong-Zhong,Chen Yao,et al.NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.[J].CANCER LETTERS.2019,451:156-167.doi:10.1016/j.canlet.2019.02.053.
APA：
Li Wan-Yu,Zhou Hong-Zhong,Chen Yao,Cai Xue-Fei,Tang Hua...&Chen Juan.(2019).NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein..CANCER LETTERS,451,
MLA：
Li Wan-Yu,et al."NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.".CANCER LETTERS 451.(2019):156-167

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