机构：[a]Vaccine Research Center, College of Life Science, Jilin University, Changchun 130012, China[b]Department of Radiotherapy, Chengdu 610041, China[c]Department of Molecular Pharmacology, Sichuan Tumor Hospital, Chengdu 610041, China临床药学部临床药学部四川省肿瘤医院
Human telomerase reverse transcriptase(hTERT) activity was detected in human nasopharyngeal carcinoma cell(CNE) but not in human normal lung fibroblas t(CCD-11Lu). Recombinant adenoviruses Ad-CMV-TK-enh and Ad-hTERT-TK-enh were constructed and infected into normal fibroblasts and nasopharyngeal carcinoma cells. Ad-CMV-TK-enh with 100 μmol/L of ganciclovir(GCV) caused 87% of CCD-11Lu cells death and 91% of CNE cells death, Ad-hTERT-TK-enh with 100 μmol/L of GCV caused 24% of CCD-11Lu cells death and 79% of CNE cells death. These results indicate that the Ad-hTERT-TK-enh with GCV may be a useful method in suppressing tumor growth in targeted nasopharyngeal carcinoma gene therapy.
语种：
外文
中科院(CAS)分区：
出版当年[2009]版：
大类|4 区化学
小类|4 区化学综合
最新[2023]版：
大类|4 区化学
小类|4 区化学：综合
第一作者：
第一作者机构：[a]Vaccine Research Center, College of Life Science, Jilin University, Changchun 130012, China[b]Department of Radiotherapy, Chengdu 610041, China
通讯作者：
通讯机构：[b]Department of Radiotherapy, Chengdu 610041, China[c]Department of Molecular Pharmacology, Sichuan Tumor Hospital, Chengdu 610041, China
推荐引用方式(GB/T 7714)：
Yu Z,Yu X.-H,Zha X,et al.Adenovirus-mediated HSV-TK gene therapy using hTERT promoter in CNE cells in vitro[J].Chemical Research in Chinese Universities.2009,25(1):
APA：
Yu, Z,Yu, X.-H,Zha, X&Kong, W.(2009).Adenovirus-mediated HSV-TK gene therapy using hTERT promoter in CNE cells in vitro.Chemical Research in Chinese Universities,25,(1)
MLA：
Yu, Z,et al."Adenovirus-mediated HSV-TK gene therapy using hTERT promoter in CNE cells in vitro".Chemical Research in Chinese Universities 25..1(2009)
