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The inhibition of EGFR nuclear translocation attenuates radioresistance through decreasing the expression of p-DNA-PK in cervical cancer cells

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作者：
Yunxiang Qi[1,2] ; Jianming Huang[2] ; Guangming Yi[2] ; Lu Li[2] ; Xiaodong Zhu[1,*1] ; Jinyi Lang[2,*2] ;
机构： [1]Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Key Laboratory of High Incidence Tumor Prevention and Treatment Guangxi Medical University, Ministry of Education, Nanning 530021, China [2]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China
出处：
ISSN：

关键词： CaSki DNA-PK EGFR Nuclear translocation PDNA-PK-T2609 PEGFR-T654

摘要：
Objective: As the leading factor for female mortality, cervical cancer with high incidence has brought huge burden to both the patients’ family and the whole society. So far radiotherapy is the general treatment for cervical cancer. However, radioresistance and metastasis at the advanced stage have become the common cause for its poor prognosis and high mortality. This study aimed to elucidate the role of epidermal growth factor receptor (EGFR) nuclear translocation in radioresistance, and its correlation with the DNA damage repair pathway in cervical cancer cells. Method: In this study, the dynamic expression of EGFR, DNA-dependent protein kinase (DNA-PK) and their phosphorylation level in irradiated cervical cancer cell line CaSki were tested by western blotting. In addition, nuclear localization signal (NLS) peptide inhibitor was synthesized to elucidate the correlation between EGFR translocation and DNA damage repair. Results: The expression of EGFR, protein kinase N1 (PKN1), and DNA-PK in the nucleus increased after irradiation in CaSki cells. Furthermore, irradiation also enhanced the phosphorylation level of EGFR at Thr654, PKN1 at T774 and DNA-PK at T2609. The inhibition of EGFR nuclear translocation decreased the expression level of EGFR and DNA-PK in the nucleus, and attenuated their phosphorylation process. Conclusion: EGFR nuclear translocation promoted DNA damage repair in irradiated cervical cancer cells. This work facilitated the investigators to understand the possible molecular mechanism of the resistance to irradiation in the treatment of cervical cancer, which provided a potentially compelling clinical method for cancer therapy. © 2017, E-Century Publishing Corporation. All rights reserved.

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外文
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出版当年[2017]版：
大类 | 4 区 医学
小类 | 4 区 医学：研究与实验
最新[2023]版：
无
第一作者：
第一作者机构： [1]Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Key Laboratory of High Incidence Tumor Prevention and Treatment Guangxi Medical University, Ministry of Education, Nanning 530021, China [2]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China
通讯作者：
通讯机构： [1]Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Cancer Institute of Guangxi Zhuang Autonomous Region, Key Laboratory of High Incidence Tumor Prevention and Treatment Guangxi Medical University, Ministry of Education, Nanning 530021, China [2]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China [*1]Department of Radiation Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China [*2]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.
推荐引用方式(GB/T 7714)：
Yunxiang Qi,Jianming Huang,Guangming Yi,et al.The inhibition of EGFR nuclear translocation attenuates radioresistance through decreasing the expression of p-DNA-PK in cervical cancer cells[J].International Journal of Clinical and Experimental Medicine.2017,10(12):
APA：
Yunxiang Qi,Jianming Huang,Guangming Yi,Lu Li,Xiaodong Zhu&Jinyi Lang.(2017).The inhibition of EGFR nuclear translocation attenuates radioresistance through decreasing the expression of p-DNA-PK in cervical cancer cells.International Journal of Clinical and Experimental Medicine,10,(12)
MLA：
Yunxiang Qi,et al."The inhibition of EGFR nuclear translocation attenuates radioresistance through decreasing the expression of p-DNA-PK in cervical cancer cells".International Journal of Clinical and Experimental Medicine 10..12(2017)

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