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DNA-dependent protein kinase in telomere maintenance and protection

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收录情况： ◇ SCIE

作者：

机构： [1]Radiation Oncology Center, Chongqing University Cancer Hospital, Chongqing 400030, China. [2]Department of Radiation Oncology, Sichuan Cancer Hospital, Chengdu, China. [3]Department of Radiation Oncology, University of Texas Southwestern Medical Center, 2201 Inwood Rd., Dallas, TX 75390–9187, USA

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关键词： DNA-PK Shelterin Telomerase Telomere hnRNP-A1

摘要：

This review focuses on DNA-dependent protein kinase (DNA-PK), which is the key regulator of canonical non-homologous end-joining (NHEJ), the predominant mechanism of DNA double-strand break (DSB) repair in mammals. DNA-PK consists of the DNA-binding Ku70/80 heterodimer and the catalytic subunit DNA-PKcs. They assemble at DNA ends, forming the active DNA-PK complex, which initiates NHEJ-mediated DSB repair. Paradoxically, both Ku and DNA-PKcs are associated with telomeres, and they play crucial roles in protecting the telomere against fusions. Herein, we discuss possible mechanisms and contributions of Ku and DNA-PKcs in telomere regulation.

基金：

基金编号： 81802740 cstc2018jcyjAX0741 RP160268 CA233594

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出版当年[2020]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学 4 区细胞生物学

最新[2023]版：

大类 | 1 区生物学

小类 | 2 区生化与分子生物学 2 区细胞生物学

JCR分区：

出版当年[2020]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CELL BIOLOGY

最新[2023]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY

影响因子： 9.2 最新[2023版] 8.1 最新五年平均 5.787 出版当年[2020版] 4.833 出版当年五年平均 3.451 出版前一年[2019版] 8.712 出版后一年[2021版]

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第一作者机构： [1]Radiation Oncology Center, Chongqing University Cancer Hospital, Chongqing 400030, China.

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