机构：[1]Department of Obstetrics and Gynecology, Hospital of Fudan University, Shanghai[2]Department of Obstetrics and Gynecology, West China Second Hospital,Sichuan University, Chengdu, Sichuan[3]Developmental and Stem Cell Institute, West China Second Hospital,Sichuan University, Chengdu, Sichuan[4]Department of Obstetrics and Gynecology,Second Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China
The cell fate determinant Numb orchestrates numerous cell physiological and pathological processes and previous evidence has indicated that Numb expression is associated with tumorigenesis. The present study investigated the potential role of Numb in endometrial cancer (EC). Numb expression was compared between the normal endometrium and EC tissue by immunohistochemistry, and the protein levels were assessed by western blotting and confocal microscopy in the human endometrial HEC-1B cancer cell line and normal epithelial cells. The intracellular localization of Numb in HEC-1B cells was examined by immunofluorescence. Numb was found to be expressed at higher levels in endometrial cancer compared with the normal endometrium. Although Numb localizes to the cytoplasm and plasma membrane in the normal epithelium, the present study found that Numb accumulated in the nucleus of HEC-1B cells. The present data reveals the upregulation of Numb expression in EC tissues and indicates that Numb plays a role in the occurrence of EC, which may be mediated by its translocation into the nucleus. The role of Numb in cancer development requires additional investigation.
基金：
This study received partial funding by the National Natural
Science Foundation of China (grant no. 81001149) and
the Shanghai Outstanding Youth Training Plan of China
(grant no. XYQ2011062).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类|4 区医学
小类|4 区肿瘤学
最新[2023]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Department of Obstetrics and Gynecology, Hospital of Fudan University, Shanghai[2]Department of Obstetrics and Gynecology, West China Second Hospital,Sichuan University, Chengdu, Sichuan
通讯作者：
通讯机构：[2]Department of Obstetrics and Gynecology, West China Second Hospital,Sichuan University, Chengdu, Sichuan[4]Department of Obstetrics and Gynecology,Second Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China[*1]Department of Obstetrics and Gynecology, Second Affiliated Hospital of Chongqing Medical University, 76 Linjiang Road, Chongqing 400010, P.R. China
推荐引用方式(GB/T 7714)：
Wang Chao,Cui Tao,Feng Weiwei,et al.Role of Numb expression and nuclear translocation in endometrial cancer.[J].Oncology letters.2015,9(4):1531-1536.doi:10.3892/ol.2015.2901.
APA：
Wang Chao,Cui Tao,Feng Weiwei,Li Huashun&Hu Lina.(2015).Role of Numb expression and nuclear translocation in endometrial cancer..Oncology letters,9,(4)
MLA：
Wang Chao,et al."Role of Numb expression and nuclear translocation in endometrial cancer.".Oncology letters 9..4(2015):1531-1536
