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PCYT1A suppresses proliferation and migration via inhibiting mTORC1 pathway in lung adenocarcinoma

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WOS体系：
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收录情况： ◇ SCIE

作者：
Jing Yu[a,b] * ; Changtao Wu[b,c] * ; Qi Wu[b] ; Jiafeng Huang[b] ; Wenjuan Fu[b] ; Xuemei Xie[d] ; Wen Li[f] ; Weizhong Tang[e] ; Chuan Xu[a,f,*1] ; Guoxiang Jin[b] ;
机构： [a]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China [b]Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), And Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China [c]Department of Colorectal and Anal Surgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, China [d]Department of Pathology, The Affiliated Hospital of North Sichuan Medical College, Nanchong, 637100, China [e]Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 530021, China [f]Integrative Cancer Center & Cancer Clinical Research Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine University of Electronic Science and Technology of China, Chengdu, 610047, China
出处：
DOI： 10.1016/j.bbrc.2020.05.164
ISSN：

关键词： Lung adenocarcinoma Migration mTORC1 signaling PCYT1A Proliferation

摘要：
Lung cancer is one of most common malignant cancer worldwide. It is emerging that PCYT1A, a rate-limiting enzyme required for the biosynthesis of phosphatidylcholine, is associated with cancer progression. However, the biological functions and underlying molecular mechanisms of PCYT1A in lung adenocarcinoma is still unknown. Here we found that PCYT1A suppressed lung adenocarcinoma cancer cell proliferation and migration. Mechanically, PCYT1A served as a novel negative regulator of mTORC1 signaling. PCYT1A knockdown enhanced the malignant proliferation and migration of lung adenocarcinoma cells by activating mTORC1. The promoting effects of PCYT1A silencing on cell proliferation and migration could be abolished when mTORC1 signaling was inhibited by rapamycin or RAPTOR depletion. Importantly, PCYT1A high expression predicted longer survival of lung cancer patients. The expression of PCYT1A was also negatively correlated with mTORC1 activation in the clinical lung cancer samples. We therefore reveal that PCYT1A suppresses proliferation and migration by inhibiting the mTORC1 signaling pathway in lung adenocarcinoma. PCYT1A shows as a potential promising biomarker in lung adenocarcinoma. © 2020 Elsevier Inc.

基金：
This study was supported by the National Natural Science Foundation of China (81773040 to G.J.); and the Chongqing Science and Technology Commission (cstc2018jcyj-yszxX0011, cstc2018jcyjAX0655 to G.J.)
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
最新[2023]版：
大类 | 3 区 生物学
小类 | 3 区 生物物理 4 区 生化与分子生物学
JCR分区：
出版当年[2020]版：
Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [a]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China [b]Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), And Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing, China
共同第一作者：
通讯作者：
通讯机构： [a]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China [f]Integrative Cancer Center & Cancer Clinical Research Center, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine University of Electronic Science and Technology of China, Chengdu, 610047, China [*1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.
推荐引用方式(GB/T 7714)：
Jing Yu,Changtao Wu,Qi Wu,et al.PCYT1A suppresses proliferation and migration via inhibiting mTORC1 pathway in lung adenocarcinoma[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2020,529(2):353-361.doi:10.1016/j.bbrc.2020.05.164.
APA：
Jing Yu,Changtao Wu,Qi Wu,Jiafeng Huang,Wenjuan Fu...&Guoxiang Jin.(2020).PCYT1A suppresses proliferation and migration via inhibiting mTORC1 pathway in lung adenocarcinoma.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,529,(2)
MLA：
Jing Yu,et al."PCYT1A suppresses proliferation and migration via inhibiting mTORC1 pathway in lung adenocarcinoma".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 529..2(2020):353-361

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