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Image guided radiation therapy boost in combination with high-dose-rate intracavitary brachytherapy for the treatment of cervical cancer

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机构: [1]Department of Radiation Oncology, Sichuan Cancer Hospital, Chengdu, China
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关键词: cervical cancer HDR brachytherapy IGRT

摘要:
Purpose: The purpose of this study was to demonstrate the dosimetric and clinical feasibility of image guided radiation therapy (IGRT) combined with high-dose-rate (HDR) intracavitary brachytherapy (ICBT) to improve dose distribution in cervical cancer treatment. Material and methods: For 42 cervical cancer patients, magnetic resonance imaging (MRI) scans were acquired after completion of whole pelvic irradiation 45-46 Gy and 5 fractions of B + I (ICBT + IGRT) treatment were subsequently received. The high risk clinical target volume (HRCTV), intermediate risk clinical target volume (IRCTV), bladder, rectum, and sigmoid were contoured on the computed tomography (CT) scans. The total planning aim doses for HRCTV was D-90% >85 Gy, whilst constraints for rectum and sigmoid were D-2cc < 75 Gy and D-2cc < 90 Gy for bladder in terms of an equivalent dose in 2 Gy (EQD2) for external beam radiotherapy (EBRT) and brachytherapy boost. The IGRT plan was optimized on top of the ICBT dose distribution. A dosimetric comparison was made between B + I and optimized ICBT (O-ICBT) only. Results: The mean D-90% of HRCTV was comparable for B + I and O-ICBT (p = 0.82). For B + I plan, HRCTV D-100%, IRCTV D-100%, and IRCTV D-90% were significantly increased by a mean of 10.52 Gy, 5.61 Gy, and 2.70 Gy, respectively (p < 0.01). The D-2cc for bladder, rectum, and sigmoid were lower by a mean of 21.36, 6.78, and 10.65 Gy, respectively (p < 0.01). The mean rectum V60 Gy value over 42 patients was almost the same for both techniques but for bladder and sigmoid B + I had higher V60 Gy mean values as compared with the O-ICBT. Conclusions: B + I can improve dose distribution in cervical cancer treatment; it could be useful for tumors extended beyond the reach of intracavitary/interstitial brachytherapy (IC/ISBT) or for centers that are inexperienced or ill-equipped with IC/ISBT techniques. Additional confirmatory prospective studies with larger numbers of patients and longer follow-up are required to validate the durability.

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出版当年[2016]版:
大类 | 4 区 医学
小类 | 4 区 肿瘤学 4 区 核医学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 肿瘤学 4 区 核医学
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出版当年[2016]版:
Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q4 ONCOLOGY
最新[2023]版:
Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q4 ONCOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

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第一作者机构: [1]Department of Radiation Oncology, Sichuan Cancer Hospital, Chengdu, China
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通讯机构: [1]Department of Radiation Oncology, Sichuan Cancer Hospital, Chengdu, China [*1]Department of Radiation Oncology, Sichuan Cancer Hospital, No.55, the 4th Section, Renmin South Road, Chengdu, 610041, China
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