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Radiobiological and dosimetric comparison of 60Co versus 192Ir high-dose-rate intracavitary-interstitial brachytherapy for cervical cancer

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机构: [1]School of Medicine, University of Electronic Science and Technology of China,Chengdu 610054, China [2]Department of Radiation Oncology, SichuanCancer Hospital and Institute, Sichuan Cancer Center, Radiation OncologyKey Laboratory of Sichuan Province, Chengdu 610041, China [3]Departmentof Health Technology and Informatics, The Hong Kong Polytechnic University,Hongkong 999077, China [4]Department of Oncology, The Affiliated Hospitalof Southwest Medical University, Luzhou 646000, Sichuan, China
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关键词: 60Co 192Ir HDR brachytherapy IC-ISBT Cervical cancer

摘要:
High-dose-rate (HDR) intracavitary-interstitial brachytherapy (IC-ISBT) is an effective treatment for bulky, middle, and advanced cervical cancer. In this study, we compared the differences between 60Co and 192Ir HDR IC-ISBT plans in terms of radiobiological and dosimetric parameters, providing a reference for clinical workers in brachytherapy.A total of 30 patients with cervical cancer receiving HDR IC-ISBT were included in this study, and IC-ISBT plans for each individual were designed with both 60Co and 192Ir at a prescribed dose of CTV D90 = 6 Gy while keeping the dose to OARs as low as possible. Physical dose and dose-volume parameters of CTV and OARs were extracted from TPS. The EQD2, EUBED, EUD, TCP, and NTCP were calculated using corresponding formulas. The differences between the 60Co and 192Ir IC-ISBT plans were compared using the paired t-test.In each patient's 60Co and 192Ir IC-ISBT plan, the average physical dose and EQD2 of 60Co were lower than those of 192Ir, and there were statistically significant differences in D2cc and D1cc for the OARs (p < 0.05); there were statistically significant differences in D0.1 cc for the bladder (p < 0.05) and no significant differences in D0.1 cc for the rectum or intestines (p > 0.05). The EUBED ratio (60Co/192Ir) at the CTV was mostly close to 1 when neither 60Co or 192Ir passed their half-lives or when both passed two half-lives, and the difference between them was not significant; at the OARs, the mean value of 60Co was lower than that of 192Ir. There was no statistical difference between 60Co and 192Ir in the EUD (93.93 versus 93.92 Gy, p > 0.05) and TCP (97.07% versus 97.08%, p > 0.05) of the tumors. The mean NTCP value of 60Co was lower than that of 192Ir.Considering the CTV and OARs, the dosimetric parameters of 60Co and 192Ir are comparable. Compared with 192Ir, the use of 60Co for HDR IC-ISBT can ensure a similar tumor control probability while providing better protection to the OARs. In addition, 60Co has obvious economic advantages and can be promoted as a good alternative to 192Ir.© 2022. The Author(s).

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出版当年[2022]版:
大类 | 2 区 医学
小类 | 2 区 核医学 3 区 肿瘤学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 核医学 3 区 肿瘤学
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出版当年[2022]版:
Q2 ONCOLOGY Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版:
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q2 ONCOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

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第一作者机构: [1]School of Medicine, University of Electronic Science and Technology of China,Chengdu 610054, China [2]Department of Radiation Oncology, SichuanCancer Hospital and Institute, Sichuan Cancer Center, Radiation OncologyKey Laboratory of Sichuan Province, Chengdu 610041, China
通讯作者:
通讯机构: [1]School of Medicine, University of Electronic Science and Technology of China,Chengdu 610054, China [2]Department of Radiation Oncology, SichuanCancer Hospital and Institute, Sichuan Cancer Center, Radiation OncologyKey Laboratory of Sichuan Province, Chengdu 610041, China
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