Relationship between mammographic calcifications and the clinicopathologic characteristics of breast cancer in Western China: a retrospective multi-center study of 7317 female patients
机构：[1]Department of Endocrine and Breast Surgery, The FirstAffiliated Hospital of Chongqing Medical University, No. 1Youyi Road, Yuzhong District, Chongqing 400016, China[2]Chongqing Key Laboratory of Molecular Oncology andEpigenetics, The First Affiliated Hospital of ChongqingMedical University, Chongqing, China[3]Department of Surgical Oncology, Affiliated Hospital ofNingxia Medical University, Yinchuan, Ningxia, China[4]Department of Breast and Neck Surgery, Affiliated TumorHospital of Xinjiang Medical University, U¨ ru¨mqi, Xinjiang,China[5]Department of Breast Surgery, Affiliated Tumor Hospital ofXinjiang Medical University, Urumqi, Xinjiang, China[6]Department of Breast Surgery, Sichuan Province TumorHospital, Chengdu, Sichuan, China[7]Department of Breast Surgery, Gan Su Province TumorHospital, Lanzhou, Gansu, China[8]Department of Breast Surgery, The First Affiliated Hospitalof Kunming Medical University, Kunming, Yunnan, China昆明医科大学附属第一医院[9]Department of Breast Surgery, Guizhou People’s Hospital,Guiyang, Guizhou, China[10]Department of Breast Surgery, GuangXi Medical UniversityAffiliated Tumor Hospital, Nanning, Guangxi, China[11]Department of Breast Surgery, Sichuan Academy of MedicalSciences & Sichuan Provincial People’s Hospital, Chengdu,Sichuan, China四川省人民医院[12]Department of Breast Surgery, West China Hospital ofSichuan University, Chengdu, Sichuan, China[13]Mammary Department, Shaanxi Provincial Tumor Hospital,Xi’an, Shaanxi, China[14]Department of Vascular and Endocrine Surgery, XijingHospital of Fourth Military Medical University, Xi’an,Shaanxi, China[15]Department of Breast Surgery, the First Affiliated Hospital ofXi’an Jiaotong University, Xi’an, Shaanxi, China[16]Department of Breast Surgery, the Third Affiliated Hospitalof Kunming Medical University, No. 519, Kunzhou Road,Xishan District, Kunming 650000, Yunnan, China[17]Breast Disease Center, Southwest Hospital, Third MilitaryMedical University, No. 29 Gaotanyan Street,Chongqing 400038, China
Limited information is available regarding the correlations between mammographic calcifications and the epidemiological features of patients with breast cancer living different lifestyles in Western China. Thus, this study aimed to investigate the relationship between mammographic calcifications and the epidemiological characteristics of female patients with breast cancer in Western China. This was a hospital-based, retrospective, multi-center epidemiological study of patients with breast cancer. Using the Western China Clinical Cooperation Group (WCCCG) database, we obtained the records of 7317 patients (with mammographic data) diagnosed with breast cancer between March 2011 and June 2016. These patients were divided into Groups I (mass alone) and II (mass combined with calcification), and their clinical and pathological data were compared. A total of 4211 patients were enrolled in Group I, and 3106 patients were enrolled in Group II. The tumors in Group II were more likely to be larger (P < 0.0001), higher grade (P = 0.0029), estrogen receptor (ER)+/progesterone receptor (PR)- (P = 0.0319), and human epidermal growth factor receptor 2 (HER-2)-positive (P < 0.0001), and to have axillary lymph node metastasis (P = 0.0033) than those in Group I. Regarding treatment, patients in Group II were more likely to have undergone chemotherapy (P = 0.0108) and anti-HER2 therapy (P = 0.0102), whereas patients in Group I were more likely to have undergone endocrine therapy (P < 0.0001). In conclusion, mammographic calcifications in tumors were associated with distinct clinicopathologic characteristics and aggressive treatments.
基金：
National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China [81202090]
第一作者机构：[1]Department of Endocrine and Breast Surgery, The FirstAffiliated Hospital of Chongqing Medical University, No. 1Youyi Road, Yuzhong District, Chongqing 400016, China
通讯作者：
通讯机构：[1]Department of Endocrine and Breast Surgery, The FirstAffiliated Hospital of Chongqing Medical University, No. 1Youyi Road, Yuzhong District, Chongqing 400016, China[2]Chongqing Key Laboratory of Molecular Oncology andEpigenetics, The First Affiliated Hospital of ChongqingMedical University, Chongqing, China
推荐引用方式(GB/T 7714)：
Ke Zheng,Jin-Xiang Tan,Fan Li,et al.Relationship between mammographic calcifications and the clinicopathologic characteristics of breast cancer in Western China: a retrospective multi-center study of 7317 female patients[J].BREAST CANCER RESEARCH AND TREATMENT.2017,166(2):569-582.doi:10.1007/s10549-017-4406-2.
APA：
Ke Zheng,Jin-Xiang Tan,Fan Li,Yu-Xian Wei,Xue-Dong Yin...&Guo-Sheng Ren.(2017).Relationship between mammographic calcifications and the clinicopathologic characteristics of breast cancer in Western China: a retrospective multi-center study of 7317 female patients.BREAST CANCER RESEARCH AND TREATMENT,166,(2)
MLA：
Ke Zheng,et al."Relationship between mammographic calcifications and the clinicopathologic characteristics of breast cancer in Western China: a retrospective multi-center study of 7317 female patients".BREAST CANCER RESEARCH AND TREATMENT 166..2(2017):569-582
