Relationship between mammographic calcifications and the clinicopathologic characteristics of breast cancer in Western China: a retrospective multi-center study of 7317 female patients
机构：[1]Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China[2]Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China[3]Department of Surgical Oncology, Affiliated Hospital of Ningxia Medical University, Yinchuan, Ningxia, China[4]Department of Breast and Neck Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China[5]Department of Breast Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China[6]Department of Breast Surgery, Sichuan Province Tumor Hospital, Chengdu, Sichuan, China外科中心乳腺外科中心乳腺科四川省肿瘤医院[7]Department of Breast Surgery, Gan Su Province Tumor Hospital, Lanzhou, Gansu, China[8]Department of Breast Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China外科科室普通外科普通外四科(乳腺外科)昆明医科大学附属第一医院[9]Department of Breast Surgery, Guizhou People’s Hospital, Guiyang, Guizhou, China[10]Department of Breast Surgery, GuangXi Medical University Affiliated Tumor Hospital, Nanning, Guangxi, China[11]Department of Breast Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China手术科室乳腺外科四川省人民医院[12]Department of Breast Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China[13]Mammary Department, Shaanxi Provincial Tumor Hospital, Xi’an, Shaanxi, China[14]Department of Vascular and Endocrine Surgery, Xijing Hospital of Fourth Military Medical University, Xi’an, Shaanxi, China[15]Department of Breast Surgery, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China[16]Department of Breast Surgery, the Third Affiliated Hospital of Kunming Medical University, No. 519, Kunzhou Road, Xishan District, Kunming 650000, Yunnan, China[17]Breast Disease Center, Southwest Hospital, Third Military Medical University, No. 29 Gaotanyan Street, Chongqing 400038, China
Limited information is available regarding the correlations between mammographic calcifications and the epidemiological features of patients with breast cancer living different lifestyles in Western China. Thus, this study aimed to investigate the relationship between mammographic calcifications and the epidemiological characteristics of female patients with breast cancer in Western China. This was a hospital-based, retrospective, multi-center epidemiological study of patients with breast cancer. Using the Western China Clinical Cooperation Group (WCCCG) database, we obtained the records of 7317 patients (with mammographic data) diagnosed with breast cancer between March 2011 and June 2016. These patients were divided into Groups I (mass alone) and II (mass combined with calcification), and their clinical and pathological data were compared. A total of 4211 patients were enrolled in Group I, and 3106 patients were enrolled in Group II. The tumors in Group II were more likely to be larger (P < 0.0001), higher grade (P = 0.0029), estrogen receptor (ER)+/progesterone receptor (PR)- (P = 0.0319), and human epidermal growth factor receptor 2 (HER-2)-positive (P < 0.0001), and to have axillary lymph node metastasis (P = 0.0033) than those in Group I. Regarding treatment, patients in Group II were more likely to have undergone chemotherapy (P = 0.0108) and anti-HER2 therapy (P = 0.0102), whereas patients in Group I were more likely to have undergone endocrine therapy (P < 0.0001). In conclusion, mammographic calcifications in tumors were associated with distinct clinicopathologic characteristics and aggressive treatments.
基金：
National Natural Science Foundation of China (NSFC) [81202090]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|3 区肿瘤学
最新[2023]版：
大类|3 区医学
小类|3 区肿瘤学
第一作者：
第一作者机构：[1]Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China
通讯作者：
通讯机构：[1]Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China[2]Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China[16]Department of Breast Surgery, the Third Affiliated Hospital of Kunming Medical University, No. 519, Kunzhou Road, Xishan District, Kunming 650000, Yunnan, China[17]Breast Disease Center, Southwest Hospital, Third Military Medical University, No. 29 Gaotanyan Street, Chongqing 400038, China
推荐引用方式(GB/T 7714)：
Ke Zheng,Jin-Xiang Tan,Fan Li,et al.Relationship between mammographic calcifications and the clinicopathologic characteristics of breast cancer in Western China: a retrospective multi-center study of 7317 female patients[J].BREAST CANCER RESEARCH AND TREATMENT.2017,166(2):569-582.doi:10.1007/s10549-017-4406-2.
APA：
Ke Zheng,Jin-Xiang Tan,Fan Li,Yu-Xian Wei,Xue-Dong Yin...&Guo-Sheng Ren.(2017).Relationship between mammographic calcifications and the clinicopathologic characteristics of breast cancer in Western China: a retrospective multi-center study of 7317 female patients.BREAST CANCER RESEARCH AND TREATMENT,166,(2)
MLA：
Ke Zheng,et al."Relationship between mammographic calcifications and the clinicopathologic characteristics of breast cancer in Western China: a retrospective multi-center study of 7317 female patients".BREAST CANCER RESEARCH AND TREATMENT 166..2(2017):569-582
