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Gastric cancer proliferation and invasion is reduced by macrocalyxin C via activation of the miR-212-3p/Sox6 Pathway.

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机构： [1]Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China [2]First Clinical Medical College of Nanjing Medical University, Nanjin, Jiangsu Province, China [3]Department of Gastroenterology, Affiliated Zhongshan Hospital of fudan university, Shanghai, China [4]Institute for Disaster Management and Reconstruction, Sichuan University-The Hong Kong Polytechnic University, Chengdu, Sichuan Province, China [5]Epidemiology of Functioning, Swiss Paraplegic Research, Nottwil, Switzerland [6]Department of Gastroenterology, Sir Run Run Hospital Affiliated with Nanjing Medical University, Nanjing, Jiangsu Province, China

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关键词： Macrocalyxin C gastric cancer miR-212-3p Sox6 anti-cancer

摘要：

Gastric cancer is a malignancy of very poor prognosis and survival rates. Macrocalyxin C is a Chinese herb-derived diterpenoid compound that has been postulated to possess anti-cancer characteristics. Gastic cell viability and stage of cell cycle were assessed using CCK8 assay and flow cytometry, respectively. Cell migration and invation were assessed using the wound healing and Transwell assays. Rate of apoptosis was determined via AV/PI-staining. Athymic nude mice xenograft models were used to evaluate the in vivo efficacy of macrocalyxin C. Western blot, luciferase experiments, cell transfection and real-time PCR allowed further study into the activation of the miR-212-3p/Sox6 pathway during macrocalyxin C treatment. We conclude that macrocalyxin C may halt the proliferation of gastric malignancies through alteration of cell invasion, apoptosis, progression through the cell cycle and cell growth. The macrocalyxin C→miR-212-3p┤Sox6 signal pathway was identified to be involved in Sox6 attenuation through augmentation of miR-212-3p values. Copyright © 2019 Elsevier Inc. All rights reserved.

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出版当年[2020]版：

大类 | 2 区生物学

小类 | 3 区细胞生物学

最新[2023]版：

大类 | 2 区生物学

小类 | 3 区细胞生物学

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出版当年[2020]版：

Q3 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY

影响因子： 4.4 最新[2023版] 4.4 最新五年平均 4.315 出版当年[2020版] 4.206 出版当年五年平均 3.968 出版前一年[2019版] 4.85 出版后一年[2021版]

第一作者：

第一作者机构： [1]Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China [2]First Clinical Medical College of Nanjing Medical University, Nanjin, Jiangsu Province, China

通讯作者：

通讯机构： [1]Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China [2]First Clinical Medical College of Nanjing Medical University, Nanjin, Jiangsu Province, China [*1]Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

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