机构：[1]Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, USA[2]Key Laboratory of Radiation Physics and Technology, Institute of Nuclear Science and Technology, Sichuan University[3]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Chengdu, China四川省肿瘤医院[4]Global Oncology One, Houston, USA[5]Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
Background and purpose: We hypothesized that a plan's robustness to anatomical changes can be improved by optimizing with multiple CT scans of a patient. The purpose of this study was to determine whether an intensity modulated proton therapy (IMPT) plan could be developed to meet dose criteria on both planning and adaptive CT plans. Material and methods: Eight lung cancer patients who underwent adaptive IMPT were retrospectively selected. Each patient had two CTs: a primary planning CT (PCT) and an adaptive planning CT (ACT), and IMPT plans associated with the scans. PCT and ACT were then used in combination to optimize one plan (MCT plan). The doses to the target and organs at risk from the PCT plan, ACT plan, P-ACT plan (PCT plan calculated on ACT data), and MCT plans calculated on both CTs were compared. Results: The MCT plan maintained the D95% on both CTs (mean, 65.99 Gy on PCT and 66.02 Gy on ACT). Target dose coverage on ACT was significantly better with the MCT plan than with the P-ACT plan (p = 0.01). MCT plans had slightly higher lung V20 (0.6%, p = 0.02) than did PCT plans. The various plans showed no statistically significant difference in heart and spinal cord dose. Conclusions: The results of this study indicate that an IMPT plan can meet the dose criteria on both PCT and ACT, and that MCT optimization can improve the plan's robustness to anatomical change. (C) 2017 Elsevier B.V. All rights reserved.
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外文
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PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|2 区医学
小类|2 区肿瘤学2 区核医学
最新[2023]版：
大类|1 区医学
小类|2 区肿瘤学2 区核医学
JCR分区：
出版当年[2018]版：
Q1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ1ONCOLOGY
最新[2023]版：
Q1ONCOLOGYQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[1]Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, USA[2]Key Laboratory of Radiation Physics and Technology, Institute of Nuclear Science and Technology, Sichuan University[3]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Chengdu, China
通讯作者：
通讯机构：[1]Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, USA[*1]Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, 1840 Old Spanish Trail, Houston, TX, USA
推荐引用方式(GB/T 7714)：
Wang Xianliang,Li Heng,Zhu Xiaorong Ronald,et al.Multiple-CT optimization of intensity-modulated proton therapy - Is it possible to eliminate adaptive planning?[J].RADIOTHERAPY AND ONCOLOGY.2018,128(1):167-173.doi:10.1016/j.radonc.2017.09.032.
APA：
Wang, Xianliang,Li, Heng,Zhu, Xiaorong Ronald,Hou, Qing,Liao, Li...&Zhang, Xiaodong.(2018).Multiple-CT optimization of intensity-modulated proton therapy - Is it possible to eliminate adaptive planning?.RADIOTHERAPY AND ONCOLOGY,128,(1)
MLA：
Wang, Xianliang,et al."Multiple-CT optimization of intensity-modulated proton therapy - Is it possible to eliminate adaptive planning?".RADIOTHERAPY AND ONCOLOGY 128..1(2018):167-173
医学