机构：[1]Department of Gynecologic Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital affiliate to School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China四川省人民医院四川省肿瘤医院[2]Department of Ultrasound, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital affiliate to School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China四川省人民医院四川省肿瘤医院[3]Department of Thoracic Surgery, the Affiliated Hospital of Chengdu University, Chengdu 610000, China[4]Department of Biochemistry & Molecular Biology, Sichuan Cancer Hospital & Institute, Cancer Hospital Affiliated to School of Medicine, University of Electronic Science and Technology of China, Chengdu 610000, China四川省人民医院四川省肿瘤医院
Perineural invasion (PNI) in early-stage cervical cancer, is associated with multiple high-risk factors and represents a poor outcome in the patients. For nerve-sparing radical hysterectomy (NSRH) to become a standard and widely used treatment for cervical cancer, we need to define its ontological safety, and to establish standardized surgical procedures and indications of NSRH. Here, we review the definition and mechanisms, and clinical significance of PNI in cervical cancer, and discuss the indications of NSRH. PNI should be regarded as one of the main pathological features of cervical cancer and a factor affecting prognosis. A deeper understanding of PNI in cervical cancer, hopefully, will provide clear indications of NSRH.
基金：
Sichuan Government; Sichuan Applied Basic Research Project from Sichuan Provincial Science and Technology Department [2017JY0300]
第一作者机构：[1]Department of Gynecologic Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital affiliate to School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China[2]Department of Ultrasound, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital affiliate to School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China
通讯作者：
通讯机构：[1]Department of Gynecologic Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital affiliate to School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China[*1]Department of Gynecologic, Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital affiliate to School of Medicine, University of Electronic Science and Technology of China, No. 55, Section 4, South People’s Road, Chengdu 610041, China
推荐引用方式(GB/T 7714)：
Zhu Yi,Zhang Guo-Nan,Shi Yu,et al.Perineural invasion in cervical cancer: pay attention to the indications of nerve-sparing radical hysterectomy[J].ANNALS OF TRANSLATIONAL MEDICINE.2019,7(9):doi:10.21037/atm.2019.04.35.
APA：
Zhu, Yi,Zhang, Guo-Nan,Shi, Yu,Cui, Ling,Leng, Xue-Feng&Huang, Jian-Ming.(2019).Perineural invasion in cervical cancer: pay attention to the indications of nerve-sparing radical hysterectomy.ANNALS OF TRANSLATIONAL MEDICINE,7,(9)
MLA：
Zhu, Yi,et al."Perineural invasion in cervical cancer: pay attention to the indications of nerve-sparing radical hysterectomy".ANNALS OF TRANSLATIONAL MEDICINE 7..9(2019)
