机构：[1]Departments of Gynecological Oncology,Sichuan Cancer Hospital & Institute, Cancer HospitalAffiliated to School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041四川省人民医院四川省肿瘤医院[2]Departments of Ultrasound, Sichuan Cancer Hospital & Institute, Cancer HospitalAffiliated to School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041四川省人民医院四川省肿瘤医院[3]Graduate School, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021[4]Department of Gynecology, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610057[5]Department of Pathology, Sichuan Cancer Hospital & Institute, Cancer Hospital Affiliated to School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China四川省人民医院四川省肿瘤医院
Perineural invasion (PNI) is the neoplastic invasion of nerves by cancer cells, a process that has attracted attention as a novel prognostic factor for cancer. The present study aimed to investigate the prognostic value of PNI in patients with early-stage cervical cancer (International Federation of Gynecology and Obstetrics stage IA2-IIA). A total of 210 patients who underwent radical hysterectomy and pelvic lymphadenectomy between 2007 and 2012 were included in the current study, of whom 8.57% (18/210) exhibited PNI. Patients with PNI were more likely to exhibit adverse histopathological features, such as increased tumor size, depth of stromal invasion, parametrial invasion, lymphovascular space invasion and lymph nodes metastases (all P<0.05). Patients with PNI exhibited shorter disease-free and overall survival (P=0.002 and P=0.017, respectively). However, PNI was not identified as an independent risk factor for either recurrence or death by multivariate analysis. Furthermore, 88.9% (16/18) of patients with PNI received adjuvant therapy following surgery. PNI was significantly associated with well-established indicators for adjuvant therapy. In conclusion, PNI was associated with multiple high-risk factors and its presence was indicative of a poor outcome in patients with early-stage cervical cancer, which may influence management decisions regarding adjuvant therapy.
第一作者机构：[1]Departments of Gynecological Oncology,Sichuan Cancer Hospital & Institute, Cancer HospitalAffiliated to School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041[2]Departments of Ultrasound, Sichuan Cancer Hospital & Institute, Cancer HospitalAffiliated to School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041
通讯作者：
通讯机构：[1]Departments of Gynecological Oncology,Sichuan Cancer Hospital & Institute, Cancer HospitalAffiliated to School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041[3]Graduate School, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021[4]Department of Gynecology, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610057[*1]Department of Gynecological Oncology, Sichuan Cancer Hospital & Institute, Cancer Hospital Affiliated to School of Medicine, University of Electronic Science and Technology of China, 55, Section 4, South People's Road, Chengdu, Sichuan 610041, P.R. China
推荐引用方式(GB/T 7714)：
YI ZHU,GUONAN ZHANG,YAN YANG,et al.Perineural invasion in early-stage cervical cancer and its relevance following surgery[J].ONCOLOGY LETTERS.2018,15(5):6555-6561.doi:10.3892/ol.2018.8116.
APA：
YI ZHU,GUONAN ZHANG,YAN YANG,LING CUI,SHIJUN JIA...&SHIQIANG XU.(2018).Perineural invasion in early-stage cervical cancer and its relevance following surgery.ONCOLOGY LETTERS,15,(5)
MLA：
YI ZHU,et al."Perineural invasion in early-stage cervical cancer and its relevance following surgery".ONCOLOGY LETTERS 15..5(2018):6555-6561
