机构：[1]Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan[2]Department of Medical Biology and Histology, School of Biomedicine, Health Sciences University of Mongolia, Ulaanbaatar, Mongolia[3]National Center for Communicable Diseases, Ulaanbaatar, Mongolia[4]National Center of Pathology, Ulaanbaatar, Mongolia[5]National Center for Maternal and Child Health, Ulaanbaatar, Mongolia[6]Department of Surgery, State Central First Hospital, Ulaanbaatar, Mongolia[7]Institute of Parasitic Diseases, Sichuan Centers for Disease Control and Prevention, Chengdu, China[8]Institute of Veterinary Medicine, Ulaanbaatar, Mongolia[9]Mongolian Academy of Science, Ulaanbaatar, Mongolia
Cystic echinococcosis (CE) is a globally distributed cestode zoonosis that causes hepatic cysts. Although Echinococcus granulosus sensu stricto (s.s.) is the major causative agent of CE worldwide, recent molecular epidemiological studies have revealed that E. canadensis is common in countries where camels are present. One such country is Mongolia.Forty-three human hepatic CE cases that were confirmed histopathologically at the National Center of Pathology (NCP) in Ulaanbaatar (UB) were identified by analysis of mitochondrial cox 1 gene as being caused by either E. canadensis (n=31, 72.1%) or E. granulosus s.s. (n=12, 27.9%). The majority of the E. canadensis cases were strain G6/7 (29/31, 93.5%). Twenty three haplotypes were identified. Sixteen of 39 CE cases with data on age, sex and province of residence were citizens of UB (41.0%), with 13 of the 16 cases from UB caused by E. canadensis (G6/7) (81.3%). Among these 13 cases, nine were children (69.2%). All pediatric cases (n = 18) were due to E. canadensis with 17 of the 18 cases (94.4%) due to strain G6/7. Serum samples were available for 31 of the 43 CE cases, with 22 (71.0%) samples positive by ELISA to recombinant Antigen B8/1 (rAgB). Nine of 10 CE cases caused by E. granulosus s.s. (90.0%) and 13 of 20 CE cases by E. canadensis (G6/7) (65.0%) were seropositive. The one CE case caused by E. canadensis (G10) was seronegative. CE cases caused by E. granulosus s.s. showed higher absorbance values (median value 1.131) than those caused by E. canadensis (G6/7) (median value 0.106) (p = 0.0137).The main species/strains in the study population were E. canadenis and E. granulossus s.s. with E. canadensis the predominant species identified in children. The reason why E. canadensis appears to be so common in children is unknown.
基金：
The studies were supported by Grant-in-Aid for scientific research (21256003 and 24256002), Asia-Africa Scientific Platform Funds (2006-2008, 2009-
2011) from the Japan Society for the Promotion of Science, the Hokkaido Translational Research Fund (2007-2011) and the Special Coordination Fund for
Promoting Science and Technology (2010-2012) from the Ministry of Education, Culture, Sports, Science & Technology in Japan (MEXT) to AI. The funders had no
role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|2 区医学
小类|1 区热带医学2 区寄生虫学
最新[2023]版：
大类|2 区医学
小类|1 区热带医学2 区寄生虫学
第一作者：
第一作者机构：[1]Department of Parasitology, Asahikawa Medical University, Asahikawa, Japan
通讯作者：
推荐引用方式(GB/T 7714)：
Ito Akira,Dorjsuren Temuulen,Davaasuren Anu,et al.Cystic echinococcoses in Mongolia: molecular identification, serology and risk factors[J].PLoS neglected tropical diseases.2014,8(6):e2937.doi:10.1371/journal.pntd.0002937.
APA：
Ito Akira,Dorjsuren Temuulen,Davaasuren Anu,Yanagida Tetsuya,Sako Yasuhito...&Chuluunbaatar Gantigmaa.(2014).Cystic echinococcoses in Mongolia: molecular identification, serology and risk factors.PLoS neglected tropical diseases,8,(6)
MLA：
Ito Akira,et al."Cystic echinococcoses in Mongolia: molecular identification, serology and risk factors".PLoS neglected tropical diseases 8..6(2014):e2937
医学