机构：[1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China四川省人民医院四川省肿瘤医院[2]Department of Human Sperm Bank, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China[3]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
With development of tumor treatment, survival time of patients with cancer is significantly prolonged. Therefore, the current emphasis is not only the survival, but also the quality of life, especially, it is crucial for young male cancer patients who are unmarried and maintaining fertility. However, the awareness of fertility preservation for these patients is currently insufficient. To give physician and cancer patients more clear understanding of the importance and safety of sperm cryopreservation, so that achieve patient fertility benefits. First, the knowledge level and attitudes about fertility preservation were investigated by surveying 332 cancer patients and 103 medical staff with questionnaires. Second, 30 male cancer patients (experimental group) and 30 normal donors (control group) were selected and their sperm samples were cryopreserved. The sperm quality was compared between cancer patients and normal donors, before and after antitumor treatment in the cancer patients, and before and after sperm cryopreservation in both groups. In the questionnaire survey, we found that there were 70% to 80% of medical staffs and cancer patients lacked knowledge of fertility preservation, and 27.7% of patients worried that tumor and sperm cryopreservation might affect their offspring. In the sperm preservative experiment, we found that sperm quality in cancer patients was further damaged after radiotherapy/chemotherapy in addition to tumor itself had a negative effect. However, sperm deoxyribonucleic acid fragments were not affected by sperm cryopreservation although there were significant differences in sperm quality before and after sperm preservation in both groups. Radiotherapy/chemotherapy would further damage sperm quality of young male cancer patients. Medical staff should be aware of importance of sperm cryopreservation for fertility preservation for these patients. It is also necessary that medical staff should inform the patient about the safety of sperm freezing and guide the patient to participate in sperm cryopreservation.
基金：
Scientific Research of Sichuan Province Health Department
第一作者机构：[1]Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Human Sperm Bank, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China[3]Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.[*1]West China Second University Hospital of Sichuan Hospital, Chengdu, Sichuan, China
推荐引用方式(GB/T 7714)：
Li Yinfeng,Zhang Jian,Zhang Hanfeng,et al.Importance and safety of autologous sperm cryopreservation for fertility preservation in young male patients with cancer[J].MEDICINE.2020,99(15):doi:10.1097/MD.0000000000019589.
APA：
Li, Yinfeng,Zhang, Jian,Zhang, Hanfeng,Liu, Bo,Wang, Guorong...&Jiang, Xiaohui.(2020).Importance and safety of autologous sperm cryopreservation for fertility preservation in young male patients with cancer.MEDICINE,99,(15)
MLA：
Li, Yinfeng,et al."Importance and safety of autologous sperm cryopreservation for fertility preservation in young male patients with cancer".MEDICINE 99..15(2020)
