机构：[1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China四川大学华西医院[2]Department of Radiation Oncology, Sichuan Cancer Center, Sichuan Cancer Hospital and Institute, School of Medicine University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China四川省肿瘤医院
The use of partial nephrectomy (PN) to treat patients with large renal cell carcinoma (RCC) remains controversial, particularly among elderly patients. The present study compared the improvement in cancer-specific survival (CSS) in patients with pT1b RCC who underwent either PN or radical nephrectomy (RN) and investigated the effects of age and sex on CSS. A total of 20,343 patients were identified in the Surveillance, Epidemiology and End Results database. Kaplan-Meier curves and Cox regression analysis were used to compare the CSS of patients who received PN vs. those who received RN. In total, 5,375 (26.42%) and 14,968 (73.58%) patients with pT1b RCC received PN and RN, respectively. Kaplan-Meier and Cox regression analysis indicated that PN resulted in an improved CSS compared with RN (P<0.001). In addition, PN was observed to be beneficial in male (P<0.001) and female patients <75 years of age. However, it was not beneficial for female patients of >= 75 years of age (P=0.197). These preliminary results warrant further investigation in clinical trials.
基金：
1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University [ZY2016104]
第一作者机构：[1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China[2]Department of Radiation Oncology, Sichuan Cancer Center, Sichuan Cancer Hospital and Institute, School of Medicine University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China
通讯作者：
通讯机构：[1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China[*1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 37 Guoxuexiang Street, Chengdu, Sichuan 610041, P.R. China
推荐引用方式(GB/T 7714)：
Liu Xiaode,Huang Xuemei,Zhao Pan,et al.Survival benefit of nephron-sparing surgery for patients with pT1b renal cell carcinoma: A population-based study[J].ONCOLOGY LETTERS.2020,19(1):498-504.doi:10.3892/ol.2019.11065.
APA：
Liu, Xiaode,Huang, Xuemei,Zhao, Pan&Zhang, Peng.(2020).Survival benefit of nephron-sparing surgery for patients with pT1b renal cell carcinoma: A population-based study.ONCOLOGY LETTERS,19,(1)
MLA：
Liu, Xiaode,et al."Survival benefit of nephron-sparing surgery for patients with pT1b renal cell carcinoma: A population-based study".ONCOLOGY LETTERS 19..1(2020):498-504
