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Comparative analysis of salvage partial nephrectomy versus radical nephrectomy after the failure of initial partial nephrectomy

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收录情况： ◇ SCIE

作者：
Huang Jiwei[1] * ; Su Ruopeng[1] * ; Zhang Cuijian[2] * ; Bao Yige[3] * ; Hu Xiaoyi[4] * ; Ye Xiongjun[5] * ; Chen Minfeng[6] * ; Wang Ping[7] * ; Wu Jitao[8] * ; Wang Yueming[1] * ; Tang Qi[2] * ; Huang Zhiyang[9] ; Zheng Bing[10] ; Li Chancan[11] ; Guo Jianming[4] ; Huang Yiran[1] ; Wei Qiang[3] ; He Zhisong[2] ; Xue Wei[1] ;
机构： [1]Department of Urology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China [2]Department of Urology, First Hospital of Peking University, Institute of Urology, Peking University, National Urological Cancer Center, Xicheng District, Beijing, P. R. China [3] Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu, China [4]Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China [5]Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China [6]Department of Urology, Xiangya Hospital, Central South University, Changsha, China [7]Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China [8]Department of Urology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China [9]Department of Urology, Quanzhou First Hospital affiliated to Fujian Medical University, Quanzhou, China [10] The Department of Urology, The Second Affiliated Hospital of Nantong University, Nantong, China [11]The Department of Urology, AnHui NO.2 Provincial People Hospital, Hefei, China
出处：
DOI： 10.1016/j.urolonc.2023.07.010
ISSN：

关键词： Partial nephrectomy Radical nephrectomy Renal function Salvage surgery Renal cell carcinoma

摘要：
To compare the oncologic outcomes and renal function discrepancy of salvage partial nephrectomy (sPN) and salvage radical nephrectomy (sRN) after an initial failed PN.Retrospective data from multiple centers between 2008 and 2022 were analyzed in this study. Patients who received sPN or sRN after an initial failed PN were identified. Comparative analysis and propensity score matching (PSM) was performed and the RENAL score, tumor size, and pathological T stage at salvage surgery were used to match the 2 groups. Local recurrence-free survival (LRFS) and recurrence-free survival (RFS) were assessed using the Cox proportional hazards model and log-rank tests. Renal function after salvage surgery was assessed using the Wilcoxon rank sum test.A total of 140 patients who underwent salvage surgery were evaluated, of whom 60 were considered for PSM analysis after matching. At a median follow-up of 27.0 months, LRFS and RFS showed no significant difference between sPN and sRN, either before (LRFS, HR = 0.673 [95% CI: 0.171-2.644], P = 0.610; RFS, HR = 0.744 [95% CI: 0.271-1.344], P = 0.595) or after matching (LRFS, HR = 1.080 [95% CI: 0.067-17.30], P = 0.957; RFS, HR = 1.199 [95% CI: 0.241-5.983], P = 0.822). During long-term follow-up, sPN preserved renal function (after matching, eGFR, 71.4 vs. 54.0, P < 0.001) and prevented eGFR loss (after matching: 6.6% vs. 25.6%, P < 0.001).Salvage partial nephrectomy offers a better alternative than sRN for recurrence after initial PN, as sPN preserves renal function better while maintaining parallel tumor control and acceptable complication rates.Copyright © 2023 Elsevier Inc. All rights reserved.

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外文
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中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 泌尿学与肾脏学 4 区 肿瘤学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 泌尿学与肾脏学 4 区 肿瘤学
JCR分区：
出版当年[2023]版：
Q2 UROLOGY & NEPHROLOGY Q3 ONCOLOGY
最新[2023]版：
Q2 UROLOGY & NEPHROLOGY Q3 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Urology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Huang Jiwei,Su Ruopeng,Zhang Cuijian,et al.Comparative analysis of salvage partial nephrectomy versus radical nephrectomy after the failure of initial partial nephrectomy[J].UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS.2023,41(10):434e17-434e25.doi:10.1016/j.urolonc.2023.07.010.
APA：
Huang Jiwei,Su Ruopeng,Zhang Cuijian,Bao Yige,Hu Xiaoyi...&Xue Wei.(2023).Comparative analysis of salvage partial nephrectomy versus radical nephrectomy after the failure of initial partial nephrectomy.UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS,41,(10)
MLA：
Huang Jiwei,et al."Comparative analysis of salvage partial nephrectomy versus radical nephrectomy after the failure of initial partial nephrectomy".UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 41..10(2023):434e17-434e25

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