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Magnetic and fluorescent Gd

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机构： [a]School of Electronics and Information Technology and School of Physics, Guangzhou, China [b]State Key Laboratory of Oncology in South China, Imaging Diagnosis and Interventional Center, Guangzhou, China [c]Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China [d]Department of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China [e]State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-Sen University, Guangzhou, China [f]State Key Laboratory of Oncology in South China, Imaging Diagnosis and Interventional Center, Sun Yat-Sen University, Guangzhou, 510275, China

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关键词： MR imaging Photodynamic therapy Singlet oxygen Upconversion luminescence imaging Upconversion nanoparticles

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The development of upconversion nanoparticles (UCNs) for theranostics application is a new strategy toward the accurate diagnosis and efficient treatment of cancer. Here, magnetic and fluorescent lanthanide-doped gadolinium oxide (Gd 2 O 3 ) UCNs with bright upconversion luminescence (UCL) and high longitudinal relaxivity (r 1 ) are used for simultaneous magnetic resonance imaging (MRI)/UCL dual-modal imaging and photodynamic therapy (PDT). In vitro and in vivo MRI studies show that these products can serve as good MRI contrast agents. The bright upconversion luminescence of the products allows their use as fluorescence nanoprobes for live cells imaging. We also utilized the luminescence-emission capability of the UCNs for the activation of a photosensitizer to achieve significant PDT results. To the best of our knowledge, this study is the first use of lanthanide-doped Gd 2 O 3 UCNs in a theranostics application. This investigation provides a useful platform for the development of Gd 2 O 3 -based UCNs for clinical diagnosis, treatment, and imaging-guided therapy of cancer. © 2017 Liu et al.

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出版当年[2017]版：

大类 | 2 区工程技术

小类 | 2 区药学 3 区纳米科技

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区药学 3 区纳米科技

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第一作者机构： [a]School of Electronics and Information Technology and School of Physics, Guangzhou, China

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