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Novel biomarkers of nasopharyngeal carcinoma metastasis risk identified by reverse phase protein array based tumor profiling with consideration of plasma Epstein-Barr virus DNA load

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机构: [1]First Peoples Hosp Foshan, Dept Radiat Oncol Canc Ctr, Foshan P R, Peoples R China; [2]Sun Yat Sen Univ, Zhongshan Sch Med, Dept Pathophysiol, Guangzhou, Guangdong, Peoples R China; [3]Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA; [4]Sun Yat Sen Univ, Dept Nasopharyngeal Carcinoma, Ctr Canc, Guangzhou, Guangdong, Peoples R China; [5]First Peoples Hosp Foshan, Dept Med Oncol, Ctr Canc, Foshan, Peoples R China; [6]Univ Texas Grad Sch Biomed Sci Houston, Expt Therapeut Acad Program, Houston, TX USA; [7]Univ Texas Grad Sch Biomed Sci Houston, Canc Biol Program, Houston, TX USA; [8]Abbvie Inc, 1 North Waukegan Rd, N Chicago, IL 60064 USA; [9]Univ Texas MD Anderson Canc Ctr, Unit 1058, Dept Syst Biol, 1515 Holcombe Blvd, Houston, TX 77030 USA
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关键词: Biomarkers Epstein-Barr virus (EBV) Metastasis Nasopharyngeal carcinoma Reverse phase protein array (RPPA)

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PurposeIn patients with Epstein-Barr virus (EBV) associated nasopharyngeal carcinoma (NPC), intertumor heterogeneity causes interpatient heterogeneity in the risk of distant metastasis. We aimed to identify novel biomarkers of metastasis risk using reverse phase protein array (RPPA) profiling of NPC patients at risk for metastasis and considering plasma EBV DNA load. Experimental designA total of 98 patients with NPC with and without metastasis after treatment, matched with respect to clinical parameters, are enrolled. Total protein expression is measured by RPPA, and protein functions are analyzed by pathway bioinformatics. ResultsThe RPPA analysis revealed a profile of 70 proteins that are differentially expressed in metastatic and nonmetastatic tumors. Plasma EBV DNA load after treatment correlated with protein expression level better than plasma EBV DNA load before treatment did. The biomarkers of NPC metastasis identified by proteomics regulate signaling pathways involved in cell cycle progression, apoptosis, and epithelial-mesenchymal transition. The authors identified 26 biomarkers associated with 5-year distant failure-free survival in univariate analysis; five biomarkers remained significant in multivariate analysis. Conclusions and clinical relevanceA comprehensive RPPA profiling study is warranted to identify novel metastasis-related biomarkers and further examine the activation state of signaling proteins to improve estimation of metastasis risk for patients with EBV-associated NPC.

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出版当年[2017]版:
大类 | 3 区 医学
小类 | 3 区 生化研究方法
最新[2023]版:
大类 | 4 区 生物学
小类 | 4 区 生化研究方法
第一作者:
第一作者机构: [1]First Peoples Hosp Foshan, Dept Radiat Oncol Canc Ctr, Foshan P R, Peoples R China; [2]Sun Yat Sen Univ, Zhongshan Sch Med, Dept Pathophysiol, Guangzhou, Guangdong, Peoples R China; [3]Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA;
通讯作者:
通讯机构: [2]Sun Yat Sen Univ, Zhongshan Sch Med, Dept Pathophysiol, Guangzhou, Guangdong, Peoples R China; [3]Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA; [6]Univ Texas Grad Sch Biomed Sci Houston, Expt Therapeut Acad Program, Houston, TX USA; [7]Univ Texas Grad Sch Biomed Sci Houston, Canc Biol Program, Houston, TX USA; [9]Univ Texas MD Anderson Canc Ctr, Unit 1058, Dept Syst Biol, 1515 Holcombe Blvd, Houston, TX 77030 USA
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