TP53, a tumor suppressor gene, plays a critical role in cell cycle control, apoptosis, and DNA damage repair. Previous studies have indicated that the TP53 gene Arg72Pro (rs1042522 C>G) polymorphism is associated with susceptibility to various types of cancer. We evaluated the association of the TP53 gene rs1042522 C>G polymorphism with neuroblastoma susceptibility in a hospital-based study among the Chinese Han population. Enrolled were 256 patients and 531 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) generated using logistic regression models were used to determine the strength of the association of interest. No association was detected between rs1042522 C>G polymorphism and neuroblastoma risk. In our stratification analysis of age, gender, sites of origin, and clinical stages, we observed that subjects with rs1042522 CG/GG genotypes had a lower risk of developing neuroblastoma in the mediastinum (Adjusted OR=0.52, 95% CI=0.33-0.82, P=0.005) than those carrying the CC genotype. These results indicate that TP53 gene rs1042522 C>G polymorphism may exert a weak and site-specific effect on neuroblastoma risk in Southern Chinese children and warrant further confirmation.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81502046]; State Clinical Key Specialty Construction Project (Pediatric Surgery) [GJLCZD1301]; Clinical Medicine Research and Transformation Center of Brain Injury in Premature Infants in Guangzhou [520101-2150092]; Guangzhou Science Technology and Innovation Commission [201607010395]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区生物
小类|3 区细胞生物学
最新[2023]版：
大类|3 区医学
小类|3 区细胞生物学3 区老年医学
第一作者：
第一作者机构：[1]Guangzhou Med Univ, Dept Pediat Surg, Guangzhou Inst Pediat, Guangzhou Women & Childrens Med Ctr, Guangzhou 510623, Guangdong, Peoples R China;[2]Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Dept Expt Res,Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China;
通讯作者：
通讯机构：[1]Guangzhou Med Univ, Dept Pediat Surg, Guangzhou Inst Pediat, Guangzhou Women & Childrens Med Ctr, Guangzhou 510623, Guangdong, Peoples R China;[2]Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Dept Expt Res,Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China;
推荐引用方式(GB/T 7714)：
He Jing,Wang Fenghua,Zhu Jinhong,et al.The TP53 gene rs1042522 C > G polymorphism and neuroblastoma risk in Chinese children[J].AGING-US.2017,9(3):852-859.doi:10.18632/aging.101196.
APA：
He, Jing,Wang, Fenghua,Zhu, Jinhong,Zhang, Zhuorong,Zou, Yan...&Xia, Huimin.(2017).The TP53 gene rs1042522 C > G polymorphism and neuroblastoma risk in Chinese children.AGING-US,9,(3)
MLA：
He, Jing,et al."The TP53 gene rs1042522 C > G polymorphism and neuroblastoma risk in Chinese children".AGING-US 9..3(2017):852-859
