Background: Published papers reported contradictory results about the correlation between bevacizumab effectiveness and primary tumor location of metastatic colorectal cancer (mCRC). Methods: 740 mCRC patients treated with chemotherapy (CT group) and 244 patients treated with bevacizumab plus chemotherapy as first-line setting (CT + B group) were included. Propensity score analyses were used for patients' stratification and matching. Kaplan-Meier curves with log-rank tests were used to detect different overall survival (OS). Results: Patients in CT + B group had similar OS comparing with CT group only when the primary tumor located at right-side colon (20.2 for CT + B versus 19.7 months for CT group, p = 0.269). For left-side colon and rectal cancer patients, significantly longer OS were observed in CT + B than CT group. Conclusion: Our data suggested only patients with left-side colon or rectal cancer could get survival benefit from the addition of bevacizumab to first-line chemotherapy.
基金：
Natural Science Foundation of Guangdong, ChinaNational Natural Science Foundation of Guangdong Province [2015A030313010]; Science and Technology Program of Guangzhou, China [1563000305]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81272641, 81572409]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2023]版：
大类|3 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China,VIP Reg, Guangzhou 510060, Guangdong, Peoples R China
通讯作者：
通讯机构：[1]Sun Yat Sen Univ, Ctr Canc, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China,VIP Reg, Guangzhou 510060, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
He Wen-Zhuo,Liao Fang-Xin,Jiang Chang,et al.Primary Tumor Location as a Predictive Factor for First-line Bevacizumab Effectiveness in Metastatic Colorectal Cancer Patients[J].JOURNAL OF CANCER.2017,8(3):388-394.doi:10.7150/jca.16804.
APA：
He, Wen-Zhuo,Liao, Fang-Xin,Jiang, Chang,Kong, Peng-Fei,Yin, Chen-Xi...&Xia, Liang-Ping.(2017).Primary Tumor Location as a Predictive Factor for First-line Bevacizumab Effectiveness in Metastatic Colorectal Cancer Patients.JOURNAL OF CANCER,8,(3)
MLA：
He, Wen-Zhuo,et al."Primary Tumor Location as a Predictive Factor for First-line Bevacizumab Effectiveness in Metastatic Colorectal Cancer Patients".JOURNAL OF CANCER 8..3(2017):388-394
