Metformin, an inexpensive and well-tolerated oral agent commonly used in the first-line treatment of type 2 diabetes, has become the focus of intense research as a candidate anticancer agent. Here, we discuss the potential of metformin in cancer therapeutics, particularly its functions in multiple signaling pathways, including AMP-activated protein kinase, mammalian target of rapamycin, insulin-like growth factor, c-Jun N-terminal kinase/mitogen-activated protein kinase (p38 MAPK), human epidermal growth factor receptor-2, and nuclear factor kappaB pathways. In addition, cutting-edge targeting of cancer stem cells by metformin is summarized.
基金：
National Natural Science Foundation of China (NSFC) Key ProjectNational Natural Science Foundation of China [81130046]; NSFCNational Natural Science Foundation of China [81171993, 81272415]; Guangxi Key Projects [2013GXNSFEA053004]; Guangxi Projects [1355004-5, 2012GXNSFCB053004]; Guangxi Ministry of Education [201202ZD022, 201201ZD004]
语种：
外文
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出版当年[2017]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Minist Educ, Key Lab Longev & Ageing Related Dis, Nanning 530021, Guangxi, Peoples R China;[2]Guangxi Med Univ, Ctr Translat Med, 14th Floor,Pharmacol & Biomed Sci Bldg, Nanning 530021, Guangxi, Peoples R China;
通讯作者：
通讯机构：[1]Minist Educ, Key Lab Longev & Ageing Related Dis, Nanning 530021, Guangxi, Peoples R China;[2]Guangxi Med Univ, Ctr Translat Med, 14th Floor,Pharmacol & Biomed Sci Bldg, Nanning 530021, Guangxi, Peoples R China;[4]Univ Michigan, Sch Med, Dept Urol & Pathol, Ann Arbor, MI 48109 USA;
推荐引用方式(GB/T 7714)：
Lei Yong,Yi Yanhua,Liu Yang,et al.Metformin targets multiple signaling pathways in cancer[J].CHINESE JOURNAL OF CANCER.2017,36(1):-.doi:10.1186/s40880-017-0184-9.
APA：
Lei, Yong,Yi, Yanhua,Liu, Yang,Liu, Xia,Keller, Evan T....&Lu, Yi.(2017).Metformin targets multiple signaling pathways in cancer.CHINESE JOURNAL OF CANCER,36,(1)
MLA：
Lei, Yong,et al."Metformin targets multiple signaling pathways in cancer".CHINESE JOURNAL OF CANCER 36..1(2017):-
