Objectives: The role of body mass index (BMI) in lymphoma survival outcomes is controversial. The prognostic significance of BMI in extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is unclear. We evaluated the prognostic role of BMI in patients with ENKTL. Methods: We retrospectively analyzed 742 patients with newly diagnosed ENKTL. The prognostic value of BMI was compared between patients with low BMIs (< 20.0 kg/m2) and patients with high BMIs (>= 20.0 kg/m(2)). The prognostic value of the International Prognostic Index (IPI) and the Korean Prognostic Index (KPI) was also evaluated and compared with that of the BMI classification. Results: Patients with low BMIs tended to exhibit higher Eastern Cooperative Oncology Group performance status (ECOG PS) scores (>= 2) (P = 0.001), more frequent B symptoms (P < 0.001), lower albumin levels (P < 0.001), higher KPI scores (P = 0.03), and lower rates of complete remission (P < 0.001) than patients with high BMIs, as well as inferior progression-free survival (PFS, P = 0.003), and inferior overall survival (OS, P = 0.001). Multivariate analysis demonstrated that age > 60 years, mass > 5 cm, stage III/IV, elevated LDH levels, albumin levels < 35 g/L and low BMIs were independent adverse predictors of OS. The BMI classification was found to be superior to the IPI with respect to predicting patient outcomes among low-risk patients and the KPI with respect to distinguishing between intermediate-low-and high-intermediate-risk patients. Conclusions: Higher BMI at the time of diagnosis is associated with improved overall survival in ENKTL. Using the BMI classification may improve the IPI and KPI prognostic models.
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外文
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出版当年[2017]版:
大类|2 区医学
小类|2 区肿瘤学3 区细胞生物学
最新[2023]版:
无
第一作者:
第一作者机构:[1]Hunan Canc Hosp, Dept Lymphoma & Hematol, Changsha, Hunan, Peoples R China;[2]Cent S Univ, Xiangya Sch Med, Affiliated Canc Hosp, Changsha, Hunan, Peoples R China;
通讯作者:
通讯机构:[1]Hunan Canc Hosp, Dept Lymphoma & Hematol, Changsha, Hunan, Peoples R China;[2]Cent S Univ, Xiangya Sch Med, Affiliated Canc Hosp, Changsha, Hunan, Peoples R China;[5]State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China;[6]Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou, Guangdong, Peoples R China
推荐引用方式(GB/T 7714):
Li Ya-Jun,Yi Ping-Yong,Li Ji-Wei,et al.Increased body mass index is associated with improved overall survival in extranodal natural killer/T-cell lymphoma, nasal type[J].ONCOTARGET.2017,8(3):4245-4256.doi:10.18632/oncotarget.13988.
APA:
Li, Ya-Jun,Yi, Ping-Yong,Li, Ji-Wei,Liu, Xian-Ling,Liu, Xi-Yu...&Jiang, Wen-Qi.(2017).Increased body mass index is associated with improved overall survival in extranodal natural killer/T-cell lymphoma, nasal type.ONCOTARGET,8,(3)
MLA:
Li, Ya-Jun,et al."Increased body mass index is associated with improved overall survival in extranodal natural killer/T-cell lymphoma, nasal type".ONCOTARGET 8..3(2017):4245-4256