机构:[1]Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China临床科室内科中山大学肿瘤防治中心[2]State Key Laboratory of Oncology in Southern China, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China其他部门华南肿瘤学国家重点实验室中山大学肿瘤防治中心[3]Collaborative Innovation Center of Cancer Medicine, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China[4]Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China临床科室妇科中山大学肿瘤防治中心[5]Health Management Center, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China广东省人民医院[6]Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China[7]Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, China[8]Department of Hematological Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China中山大学肿瘤防治中心[9]Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive disease with a poor prognosis, requiring risk stratification in affected patients. We designed a new prognostic model specifically for ENKTL to identify high-risk patients who need more aggressive therapy. We retrospectively reviewed 158 patients who were newly diagnosed with ENKTL. The estimated 5-year overall survival rate was 39.4 %. Independent prognostic factors included total protein (TP) < 60 g/L, fasting blood glucose (FBG) > 100 mg/dL, and Korean Prognostic Index (KPI) score a parts per thousand yen2. We constructed a new prognostic model by combining these prognostic factors: group 1 (64 cases (41.0 %)), no adverse factors; group 2 (58 cases (37.2 %)), one adverse factor; and group 3 (34 cases (21.8 %)), two or three adverse factors. The 5-year overall survival (OS) rates of these groups were 66.7, 23.0, and 5.9 %, respectively (p < 0.001). Our new prognostic model had a better prognostic value than did the KPI model alone (p < 0.001). Our proposed prognostic model for ENKTL, including the newly identified prognostic indicators, TP and FBG, demonstrated a balanced distribution of patients into different risk groups with better prognostic discrimination compared with the KPI model alone.
基金:
National Nature Science Foundation of China [81372883, 81001052]; Science and Technology Planning Project of Guangdong Province, China [2011B031800222]; Young Talents Project of Sun Yat-sen University Cancer Center; Young Talents Project of Sun Yat-sen University; Natural Science Foundation of Guangdong Province, China [8151008901000043]; NIH through MD Anderson's Cancer Center Support Grant [CA016672]
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外文
被引次数:
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PubmedID:
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出版当年[2014]版:
大类|3 区医学
小类|4 区血液学
最新[2023]版:
大类|3 区医学
小类|3 区血液学
第一作者:
第一作者机构:[1]Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China[2]State Key Laboratory of Oncology in Southern China, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China[3]Collaborative Innovation Center of Cancer Medicine, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China
共同第一作者:
通讯作者:
通讯机构:[1]Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China[2]State Key Laboratory of Oncology in Southern China, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China[3]Collaborative Innovation Center of Cancer Medicine, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China
推荐引用方式(GB/T 7714):
Qingqing Cai,Xiaolin Luo,Guanrong Zhang,et al.New prognostic model for extranodal natural killer/T cell lymphoma, nasal type[J].ANNALS OF HEMATOLOGY.2014,93(9):1541-1549.doi:10.1007/s00277-014-2089-x.
APA:
Qingqing Cai,Xiaolin Luo,Guanrong Zhang,Huiqiang Huang,Hui Huang...&Ken H. Young.(2014).New prognostic model for extranodal natural killer/T cell lymphoma, nasal type.ANNALS OF HEMATOLOGY,93,(9)
MLA:
Qingqing Cai,et al."New prognostic model for extranodal natural killer/T cell lymphoma, nasal type".ANNALS OF HEMATOLOGY 93..9(2014):1541-1549