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New prognostic model for extranodal natural killer/T cell lymphoma, nasal type

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机构: [1]Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China [2]State Key Laboratory of Oncology in Southern China, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China [3]Collaborative Innovation Center of Cancer Medicine, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China [4]Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China [5]Health Management Center, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China [6]Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China [7]Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, China [8]Department of Hematological Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China [9]Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
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关键词: Extranodal natural killer/Tcell lymphoma Prognostic model Total protein Fasting blood glucose Korean Prognostic Index

摘要:
Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive disease with a poor prognosis, requiring risk stratification in affected patients. We designed a new prognostic model specifically for ENKTL to identify high-risk patients who need more aggressive therapy. We retrospectively reviewed 158 patients who were newly diagnosed with ENKTL. The estimated 5-year overall survival rate was 39.4 %. Independent prognostic factors included total protein (TP) < 60 g/L, fasting blood glucose (FBG) > 100 mg/dL, and Korean Prognostic Index (KPI) score a parts per thousand yen2. We constructed a new prognostic model by combining these prognostic factors: group 1 (64 cases (41.0 %)), no adverse factors; group 2 (58 cases (37.2 %)), one adverse factor; and group 3 (34 cases (21.8 %)), two or three adverse factors. The 5-year overall survival (OS) rates of these groups were 66.7, 23.0, and 5.9 %, respectively (p < 0.001). Our new prognostic model had a better prognostic value than did the KPI model alone (p < 0.001). Our proposed prognostic model for ENKTL, including the newly identified prognostic indicators, TP and FBG, demonstrated a balanced distribution of patients into different risk groups with better prognostic discrimination compared with the KPI model alone.

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出版当年[2014]版:
大类 | 3 区 医学
小类 | 4 区 血液学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 血液学
第一作者:
第一作者机构: [1]Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China [2]State Key Laboratory of Oncology in Southern China, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China [3]Collaborative Innovation Center of Cancer Medicine, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China
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通讯机构: [1]Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China [2]State Key Laboratory of Oncology in Southern China, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China [3]Collaborative Innovation Center of Cancer Medicine, 651 Dong Feng RD East, Guangzhou 510060, People’s Republic of China
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