机构：[1]Univ South China, Affiliated Hosp 1, Dept Endocrine, Hengyang, Peoples R China[2]Univ South China, Affiliated Hosp 1, Ctr Gastr Canc Res Human Prov, Hengyang, Peoples R China
GABAA-receptor-associated protein like-1 (GABARAPL1) is involved in a variety of cancers. The purpose of this study was to investigate the expression, prognostic roles and functions of GABARAPL1 in triple negative breast cancer (TNBC). Quantitative real-time PCR (qRT-PCR) showed that GABARAPL1 was up regulated in both TNBC cell lines and clinical TNBC tissues. High GABARAPL1 expression level was associated with shorter overall survival (OS) and disease free survival (DFS). Furthermore, inhibition of GABARAPL1 suppressed cell proliferation, tumorigenesis, invasion and metastasis, and induced cell apoptosis. We found that metadherin (MTDH) was a downstream target of GABARAPL1. Inhibition of GABARAPL1 suppressed the mRNA and protein expression of MTDH, and overexpression of MTDH could reverse the effects of GABARAPL1 inhibition, which meant GABARAPL1 performed its function partly through MTDH. Our findings demonstrate that GABARAPL1 acts as a tumor promoter in TNBC partly through MTDH. Targeting at GABARAPL1 could be a potential therapeutic strategy for TNBC.
基金：
Science and Technology Department of Hunan Province [2015SK2020]
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区肿瘤学3 区细胞生物学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Univ South China, Affiliated Hosp 1, Dept Endocrine, Hengyang, Peoples R China
通讯作者：
通讯机构：[1]Univ South China, Affiliated Hosp 1, Dept Endocrine, Hengyang, Peoples R China
推荐引用方式(GB/T 7714)：
Ran Li,Hong Tao,Xiao Xinhua,et al.GABARAPL1 acts as a potential marker and promotes tumor proliferation and metastasis in triple negative breast cancer[J].ONCOTARGET.2017,8(43):74519-74526.doi:10.18632/oncotarget.20159.
APA：
Ran, Li,Hong, Tao,Xiao, Xinhua,Xie, Liming,Zhou, Junlin&Wen, Gebo.(2017).GABARAPL1 acts as a potential marker and promotes tumor proliferation and metastasis in triple negative breast cancer.ONCOTARGET,8,(43)
MLA：
Ran, Li,et al."GABARAPL1 acts as a potential marker and promotes tumor proliferation and metastasis in triple negative breast cancer".ONCOTARGET 8..43(2017):74519-74526
