机构：[1]Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA[2]Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, USA[3]Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA[4]Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA[5]Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan[6]Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China其他部门华南肿瘤学国家重点实验室中山大学肿瘤防治中心[7]Institute of Cancer Stem Cell, First Affiliated Hospital Collaborative Innovation Center of Oncology, Dalian Medical University, Dalian, China大连医科大学附属第一医院[8]Department of Biotechnology, Asia University, Taichung, Taiwan.
The Yes-associated protein (YAP) is an effector that transduces the output of the Hippo pathway to transcriptional modulation. Considering the role of YAP in cancers, this protein has emerged as a key node in malignancy development. In this study, we determined that Aurora A kinase acts as a positive regulator for YAP-mediated transcriptional machinery. Specifically, YAP associates with Aurora A predominantly in the nucleus. Activation of Aurora A can impinge on YAP activity through direct phosphorylation. Moreover, aberrant expression of YAP and Aurora A signaling is highly correlated with triple-negative breast cancer (TNBC). We herein provide evidence to establish the functional relevance of this newly discovered regulatory axis in TNBC.
基金：
National Institutes of Health [CA109311, CA099031]; Cancer Center Support [CA016672]; National Breast Cancer Foundation; Patel Memorial Breast Cancer Endowment Fund; University of Texas MD Anderson-China Medical University and Hospital Sister Institution Fund; Ministry of Science and Technology; International Research-intensive Centers of Excellence in Taiwan (I-RiCE) [MOST 105-2911-I-002-302]; Ministry of Health and Welfare, China Medical University Hospital Cancer Research Center of Excellence [MOHW105-TDU-B-212-134003]; Center for Biological Pathways at MD Anderson and Ting Tsung and Wei Fong Chao Research Fund
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|1 区医学
小类|1 区遗传学2 区生化与分子生物学2 区细胞生物学2 区肿瘤学
最新[2023]版：
大类|1 区医学
小类|1 区生化与分子生物学1 区遗传学2 区细胞生物学2 区肿瘤学
第一作者：
第一作者机构：[1]Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA[2]Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, USA
共同第一作者：
通讯作者：
通讯机构：[1]Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA[2]Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, USA[5]Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University, Taichung, Taiwan[8]Department of Biotechnology, Asia University, Taichung, Taiwan.[*1]Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 108, Houston 77030, TX, USA.
推荐引用方式(GB/T 7714)：
Chang S-S,Yamaguchi H.,Xia W.,et al.Aurora A kinase activates YAP signaling in triple-negative breast cancer[J].ONCOGENE.2017,36(9):1265-1275.doi:10.1038/onc.2016.292.
APA：
Chang, S-S,Yamaguchi, H.,Xia, W.,Lim, S-O,Khotskaya, Y....&Hung, M-C.(2017).Aurora A kinase activates YAP signaling in triple-negative breast cancer.ONCOGENE,36,(9)
MLA：
Chang, S-S,et al."Aurora A kinase activates YAP signaling in triple-negative breast cancer".ONCOGENE 36..9(2017):1265-1275
医学