机构：[1]Department of Gynecology, Sun Yat-Sen University Cancer Center, Guangzhou, China临床科室妇科中山大学肿瘤防治中心[2]State Key Laboratory of Oncology in South China, Guangzhou, China其他部门华南肿瘤学国家重点实验室中山大学肿瘤防治中心[3]Department of Oncology, The Second Affiliated Hospital, Nanchang University, Nanchang, China[4]Collaborative Innovation Center for Cancer Medicine, Guangzhou, China[5]Department of Radiation, Sun Yat-Sen University Cancer Center, Guangzhou, China临床科室放疗科中山大学肿瘤防治中心[6]Department of Oncology, Guangdong General Hospital, Guangzhou, China广东省人民医院
This study aimed to determine whether serum karyopherin alpha 2 levels can be used as a diagnostic biomarker for epithelial ovarian carcinoma. Karyopherin alpha 2 protein was detected by enzyme-linked immunosorbent assay in serum samples from 162 epithelial ovarian carcinoma patients and 48 healthy controls. Serum karyopherin alpha 2 levels in epithelial ovarian carcinoma patients were significantly higher than in healthy controls (p < 0.001). When a karyopherin alpha 2 serum level of 2.52 mu g/mL was used as a cut-off, the sensitivity and specificity of the assay for diagnosing epithelial ovarian carcinoma were 71.4% and 81.2%, respectively. High serum karyopherin alpha 2 levels (>485 mu g/mL) correlated with International Federation of Gynecology and Obstetrics stage (p < 0.0001), lymphatic metastasis (p = 0.045), overall survival (p = 0.001), and disease-free progression (p = 0.006). Serum karyopherin alpha 2 represents a potential diagnostic biomarker for epithelial ovarian carcinoma.
基金：
National Natural Science Foundation of China [81372275, 81460393]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|3 区肿瘤学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Department of Gynecology, Sun Yat-Sen University Cancer Center, Guangzhou, China[2]State Key Laboratory of Oncology in South China, Guangzhou, China[3]Department of Oncology, The Second Affiliated Hospital, Nanchang University, Nanchang, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Gynecology, Sun Yat-Sen University Cancer Center, Guangzhou, China[2]State Key Laboratory of Oncology in South China, Guangzhou, China[4]Collaborative Innovation Center for Cancer Medicine, Guangzhou, China[*1]Department of Gynecology, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, China.
推荐引用方式(GB/T 7714)：
Huang Long,Zhou Yun,Cao Xin-Ping,et al.KPNA2 is a potential diagnostic serum biomarker for epithelial ovarian cancer and correlates with poor prognosis[J].TUMOR BIOLOGY.2017,39(6):-.doi:10.1177/1010428317706289.
APA：
Huang, Long,Zhou, Yun,Cao, Xin-Ping,Lin, Jia-Xin,Zhang, Lan...&Zheng, Min.(2017).KPNA2 is a potential diagnostic serum biomarker for epithelial ovarian cancer and correlates with poor prognosis.TUMOR BIOLOGY,39,(6)
MLA：
Huang, Long,et al."KPNA2 is a potential diagnostic serum biomarker for epithelial ovarian cancer and correlates with poor prognosis".TUMOR BIOLOGY 39..6(2017):-
