机构：[1]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine,University of Electronic Science and Technology of China, Chengdu, China,四川省肿瘤医院[2]Radiation Oncology Key Laboratory of SichuanProvince, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Scienceand Technology of China, Chengdu, China,四川省肿瘤医院[3]Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, SichuanCancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China,外科中心胸外科中心四川省人民医院四川省肿瘤医院胸外科[4]Department of medical oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine,University of Electronic Science and Technology of China, Chengdu, China四川省肿瘤医院
Background Low serum sodium has been associated with unfavorable outcome in several cancers. The prognostic value of serum sodium in esophageal carcinoma (EC) remains unclear. This study aimed to investigate preoperative serum sodium in association with outcome and survival benefit of adjuvant therapy for patients with EC. Methods Preoperative serum sodium and clinicopathological indexes were retrospectively analyzed in 2155 patients who underwent esophagectomy at Sichuan cancer hospital. Overall survival (OS) and disease-free survival (DFS) were analyzed by using Kaplan-Meier method and Cox regression. Benefit of adjuvant therapy was estimated by using Propensity Score Matching. Results The incidence of hyponatremia and hypernatremia were 2% (43/2155) and 3.5% (76/2155) in treatment-naive patients. Both sodium disorders indicated unfavorable OS (hyponatremia, adjusted HR[95% CI] = 1.78[1.2-2.62]; hypernatremia, adjusted HR = 1.52[1.1-2.11]) and DFS (hyponatremia, adjusted HR[95% CI] = 1.52[1.03-2.23]; hypernatremia, adjusted HR = 1.45[1.06-1.99]). Decreased sodium concentrations within the normal range were associated with poor OS and DFS. Postoperative adjuvant therapy was associated with improved three-year OS (56.6 vs. 40%; adjusted HR = 0.55 [95% CI, 0.41-0.73]) and DFS (51.9 vs. 36.2%; adjusted HR = 0.63 [95% CI, 0.48-0.83]) versus surgery alone in patients with low serum sodium (Na < 139.6 mmol/liter), but not in other sodium subgroups. Meanwhile, serum sodium was inversely correlated with cell counts of leukocytes, neutrophils, monocytes and C-reactive protein levels. Conclusions These results suggested that low preoperative serum sodium is associated with poor outcome in EC patients, and may predict survival benefit of adjuvant therapy.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81602731]; Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2017YFC0113101]; Department of Science and Technology of Sichuan Province [2019YFS0378, 2018JY0277]; Cancer Research Foundation of China Anti-cancer Association for Young Scientists [CAYC18A33]; CSCO-Genecast Oncology Research Found [Y-2019Genecast-041]
第一作者机构：[1]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine,University of Electronic Science and Technology of China, Chengdu, China,[2]Radiation Oncology Key Laboratory of SichuanProvince, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Scienceand Technology of China, Chengdu, China,
通讯作者：
通讯机构：[1]Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine,University of Electronic Science and Technology of China, Chengdu, China,[2]Radiation Oncology Key Laboratory of SichuanProvince, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Scienceand Technology of China, Chengdu, China,
推荐引用方式(GB/T 7714)：
Qifeng Wang,Lin Peng,Yongtao Han,et al.Preoperative Serum Sodium Level as a Prognostic and Predictive Biomarker for Adjuvant Therapy in Esophageal Cancer[J].FRONTIERS IN ONCOLOGY.2021,10:doi:10.3389/fonc.2020.555714.
APA：
Qifeng Wang,Lin Peng,Yongtao Han,Tao Li,Wei Dai...&Bangrong Cao.(2021).Preoperative Serum Sodium Level as a Prognostic and Predictive Biomarker for Adjuvant Therapy in Esophageal Cancer.FRONTIERS IN ONCOLOGY,10,
MLA：
Qifeng Wang,et al."Preoperative Serum Sodium Level as a Prognostic and Predictive Biomarker for Adjuvant Therapy in Esophageal Cancer".FRONTIERS IN ONCOLOGY 10.(2021)
