机构：[1]Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu 610041, China[2]The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area,[3]Institute of Oncologic Pathology,Shantou University Medical College, Shantou 515041, China[4]Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, China
Tumor deposits (TDs) are now observed in esophageal cancer (EC), but the role of TDs is seldom elucidated. This study aimed to research the prognostic significance and the role of TDs in EC. The patients with primary EC, who had undergone curative esophagectomy in West China Hospital from May 2005 to May 2011 were retrospectively enrolled.
The prognosis and clinicopathological traits were compared between tumor deposits positive (TDP) and tumor deposits negative (TDN) groups in all patients and TNM 0-IV stages respectively.
In our study, 1,044 patients were enrolled, with 948 (90.8%) in TDN group and 96 (9.2%) in TDP group. TDP group had significantly more advanced EC and worse prognosis (all P<0.001) than TDN group in all patients, TNM II stage and TNM III stage. The prognosis of TDP group in TNM II stage was significantly worse than TDN patients in TNM III stage (P<0.001), and the worst prognosis was always found in patients with at least one TD regardless of the number of metastatic lymph node is.
Patients in TDP subgroup had more advanced EC and worse prognosis than those in TDN subgroup. It might be more reasonable to be regarded as an indicator of stage migration in EC.
基金：
Natural Science Foundation of China-Guangdong Joint Fund [U1301227, U0932001]; National Science Foundation of ChinaNational Natural Science Foundation of China [81360331, 81472613, 81572341]; Science & Technology Planning Project of Guangdong Province [2014A030304060]; Department of Education, Guangdong Government under the Top-tier University Development Scheme for Research and Control of Infectious Diseases
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区呼吸系统
最新[2023]版：
大类|3 区医学
小类|4 区呼吸系统
第一作者：
第一作者机构：[1]Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu 610041, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Thoracic Surgery, West China Hospital of Sichuan University, Chengdu 610041, China[*1]Department of Thoracic Surgery, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu 610041, China
推荐引用方式(GB/T 7714)：
Shang Qi-Xin,Yang Yu-Shang,Xu Li-Yan,et al.Prognostic significance and role in TNM stage of tumor deposits in esophageal cancer.[J].Journal of thoracic disease.2017,9(11):4461-4476.doi:10.21037/jtd.2017.10.60.
APA：
Shang Qi-Xin,Yang Yu-Shang,Xu Li-Yan,Li En-Min,Hu Wei-Peng&Chen Long-Qi.(2017).Prognostic significance and role in TNM stage of tumor deposits in esophageal cancer..Journal of thoracic disease,9,(11)
MLA：
Shang Qi-Xin,et al."Prognostic significance and role in TNM stage of tumor deposits in esophageal cancer.".Journal of thoracic disease 9..11(2017):4461-4476
