机构：[1]Department of Pathology, West China Hospital and National Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China[2]Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China[3]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
Hypoxia-inducible factor-1 alpha (HIF-1α) plays key roles in cell survival under both hypoxia and normoxia conditions. Regulation of HIF-1α is complex and involves numerous molecules and pathways, including post-transcriptional regulation by microRNAs (miRNAs). Although upregulation of HIF-1α has been shown to promote prostate adenocarcinoma (PCa) progression, the mechanism by which miRNAs modulate HIF-1α in prostate cancer has not been clarified. Here, we show that miR-199a-5p is underexpressed in prostate adenocarcinoma. Artificial overexpression of miR-199a-5p decreased cell proliferation, motility, and tumor angiogenesis and increased apoptosis in PCa cell liness PC-3 and DU145 by directly targeting the 3'-untranslated region (UTR) of HIF-1α mRNA, which reduced HIF-1α levels as well as downstream genes transactivated by HIF-1α (such as VEGF, CXCR4, BNIP3 and BCL-xL). Abnormalities of miR-199a-HIF regulation may contribute significantly to PCa pathogenesis and progression.
基金：
National Science Foundation of ChinaNational Natural Science Foundation of China [NSFC 81572540, 81572541, 81272820, 81272848, 81302225, 81402110]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区肿瘤学3 区细胞生物学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Department of Pathology, West China Hospital and National Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China
通讯作者：
通讯机构：[1]Department of Pathology, West China Hospital and National Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China
推荐引用方式(GB/T 7714)：
Zhong Jinjing,Huang Rui,Su Zhengzheng,et al.Downregulation of miR-199a-5p promotes prostate adeno-carcinoma progression through loss of its inhibition of HIF-1α.[J].Oncotarget.2017,8(48):83523-83538.doi:10.18632/oncotarget.18315.
APA：
Zhong Jinjing,Huang Rui,Su Zhengzheng,Zhang Mengni,Xu Miao...&Zhou Qiao.(2017).Downregulation of miR-199a-5p promotes prostate adeno-carcinoma progression through loss of its inhibition of HIF-1α..Oncotarget,8,(48)
MLA：
Zhong Jinjing,et al."Downregulation of miR-199a-5p promotes prostate adeno-carcinoma progression through loss of its inhibition of HIF-1α.".Oncotarget 8..48(2017):83523-83538
