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Oncological outcomes of patients with ductal adenocarcinoma of the prostate receiving radical prostatectomy or radiotherapy.

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收录情况： ◇ CSCD-C ◇ 卓越：梯队期刊

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机构： [1]Institute of Urology, Department of Urology, West China Hospital, Sichuan University, Chengdu, China [2]Center of Biomedical Big Data, West China Hospital, Sichuan University, Chengdu, China [3]Institute of Urology, Department of Urology, The First People’s Hospital, Penglai, China

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关键词： Ductal adenocarcinoma of the prostate Cancer specific mortality Overall mortality Radicalprostatectomy Radiotherapy

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To evaluate the oncological outcomes of ductal adenocarcinoma of the prostate (DAC) managed with radical prostatectomy (RP) or radiotherapy (RT) and optimize the proper treatment modality to DAC comprehensively. The cohorts included a total of 528 patients from the Surveillance, Epidemiology and End Results (SEER) database, 354 receiving RP and 174 receiving RT. Cox proportional hazards regressions were performed to assess cancer specific mortality (CSM) and overall mortality (OM) between treatment groups. A competing risk analysis was further conducted. Subgroup analyses by age and level of prostate-specific antigen (PSA) were performed. Propensity score matching was implemented. Patients managed with RP had lower risks of CSM and OM compared with RT (before matching: Hazard ratio [HR]=0.24, 95% confidence interval [CI] 0.13-0.47 and HR=0.26, 95% CI 0.17-0.40, respectively; after matching: HR=0.18, 95% CI 0.04-0.82 and HR=0.28, 95% CI 0.11-0.70, accordingly). Subgroup analyses demonstrated that patients in the middle tertile of the age or with lower tertile PSA level managed with RP took lower risks of OM significantly (HR=0.18, 95% CI 0.06-0.57, p<0.01 and HR=0.17, 95% CI 0.06-0.54, p<0.01). Among patients with DAC, treatment with RP was associated with better survival outcomes in comparison with RT. Patients with DAC in the middle tertile of the age and with lower tertile PSA level benefited the most from RP. © 2021 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V.

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出版当年[2021]版：

大类 | 4 区医学

小类 | 4 区泌尿学与肾脏学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区泌尿学与肾脏学

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第一作者机构： [1]Institute of Urology, Department of Urology, West China Hospital, Sichuan University, Chengdu, China

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