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Microwave ablation versus laparoscopic resection as first-line therapy for solitary 3-5-cm HCC.

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wang Zhen[1,2] ; Liu Miao[3] ; Zhang De-Zhi[4] ; Wu Song-Song[5] ; Hong Zhi-Xian[6] ; He Guang-Bin[7] ; Yang Hong[8] ; Xiang Bang-de[9] ; Li Xiao[10] ; Jiang Tian-An[11] ; Li Kai[12] ; Tang Zhe[13] ; Huang Fei[14] ; Lu Man[15] ; Chen Ji-An[14] ; Lin Yu-Cheng[5] ; Lu Xiao[7] ; Wu Yu-Quan[8] ; Zhang Xiao-Wu[10] ; Zhang Ye-Fan[16] ; Cheng Chao[11] ; Ye Huo-Lin[12] ; Wang Lan-Tian[17] ; Zhong Hua-Ge[2] ; Zhong Jian-Hong[9] ; Wang Lu[15] ; Chen Miao[18] ; Liang Fang-Fang[19] ; Chen Yi[2] ; Xu Yan-Song[20] ; Yu Xiao-Ling[1] ; Cheng Zhi-Gang[1] ; Liu Fang-Yi[1] ; Han Zhi-Yu[1] ; Tang Wei-Zhong[2] ; Yu Jie[1] ; Liang Ping[1,*1] ;
机构： [1]Department of Interventional Ultrasound, PLA Medical College & Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. [2]Guangxi Clinical Research Center for CRC, Department of Gastrointestinal Surgery, Guangxi Medical University Cancer Hospital, Nanning, China. [3]Graduate School of Chinese PLA General Hospital, Beijing, China. [4]Abdominal Ultrasound Department, the First Hospital of Jilin University, Changchun, China. [5]Department of Ultrasonography, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China. [6]Department of Hepatobiliary Surgery, PLA Medical College & Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. [7]Department of Ultrasound, Xijing Hospital, the Fourth Military Medical University, Xian, China. [8]Department of Ultrasound, the First Affiliated Hospital of Guangxi Medical University, Nanning, China. [9]Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, China. [10]Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [11]Department of Ultrasound Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. [12]Department of Ultrasound, Guangdong Key Laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. [13]Department of Surgery, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, P. R. China. [14]Department of General Surgery, the Second Affiliated Hospital of Guangxi Medical University, Nanning, China. [15]Ultrasound Medical Center, Sichuan Cancer Hospital Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. [16]Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [17]Department of Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China. [18]Department of Radiology, Guangxi Medical University Cancer Hospital, Guangxi Medical University, Nanning, P. R. China. [19]Department of Medical Oncology, the First Affiliated Hospital of Guangxi Medical University, Nanning, P. R. China. [20]Department of Emergency, the First Affiliated Hospital of Guangxi Medical University, Nanning, P. R. China.
出处：
DOI： 10.1002/hep.32323
ISSN：

摘要：
The study objective was to compare the effectiveness of microwave ablation (MWA) and laparoscopic liver resection (LLR) on solitary 3-5-cm HCC over time.From 2008 to 2019, 1289 patients from 12 hospitals were enrolled in this retrospective study. Diagnosis of all lesions were based on histopathology. Propensity score matching was used to balance all baseline variables between the two groups in 2008-2019 (n = 335 in each group) and 2014-2019 (n = 257 in each group) cohorts, respectively. For cohort 2008-2019, during a median follow-up of 35.8 months, there were no differences in overall survival (OS) between MWA and LLR (HR: 0.88, 95% CI 0.65-1.19, p = 0.420), and MWA was inferior to LLR regarding disease-free survival (DFS) (HR 1.36, 95% CI 1.05-1.75, p = 0.017). For cohort 2014-2019, there was comparable OS (HR 0.85, 95% CI 0.56-1.30, p = 0.460) and approached statistical significance for DFS (HR 1.33, 95% CI 0.98-1.82, p = 0.071) between MWA and LLR. Subgroup analyses showed comparable OS in 3.1-4.0-cm HCCs (HR 0.88, 95% CI 0.53-1.47, p = 0.630) and 4.1-5.0-cm HCCs (HR 0.77, 95% CI 0.37-1.60, p = 0.483) between two modalities. For both cohorts, MWA shared comparable major complications (both p > 0.05), shorter hospitalization, and lower cost to LLR (all p < 0.001).MWA might be a first-line alternative to LLR for solitary 3-5-cm HCC in selected patients with technical advances, especially for patients unsuitable for LLR.© 2022 American Association for the Study of Liver Diseases.

基金：
Supported by the National Scientific Foundation Committee of China (91859201,92159305, 81971625, 82030047).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 胃肠肝病学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 胃肠肝病学
JCR分区：
出版当年[2022]版：
Q1 GASTROENTEROLOGY & HEPATOLOGY
最新[2023]版：
Q1 GASTROENTEROLOGY & HEPATOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Interventional Ultrasound, PLA Medical College & Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. [2]Guangxi Clinical Research Center for CRC, Department of Gastrointestinal Surgery, Guangxi Medical University Cancer Hospital, Nanning, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Interventional Ultrasound, PLA Medical College & Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. [*1]Department of Interventional Ultrasound, Chinese PLA General Hospital, The Fifth Medical Center, 28 Fuxing Road, Beijing, 100853, China
推荐引用方式(GB/T 7714)：
Wang Zhen,Liu Miao,Zhang De-Zhi,et al.Microwave ablation versus laparoscopic resection as first-line therapy for solitary 3-5-cm HCC.[J].HEPATOLOGY.2022,76(1):66-77.doi:10.1002/hep.32323.
APA：
Wang Zhen,Liu Miao,Zhang De-Zhi,Wu Song-Song,Hong Zhi-Xian...&Liang Ping.(2022).Microwave ablation versus laparoscopic resection as first-line therapy for solitary 3-5-cm HCC..HEPATOLOGY,76,(1)
MLA：
Wang Zhen,et al."Microwave ablation versus laparoscopic resection as first-line therapy for solitary 3-5-cm HCC.".HEPATOLOGY 76..1(2022):66-77

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