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Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration

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机构： [1]Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. [2]Department of Hematology and Institute of Hematology, West China Hospital, Sichuan University, Chengdu, 610041, China. [3]Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China. [4]Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China. [5]Departments of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.

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关键词： bioactive molecule delivery biomaterial properties bone regeneration immune modulation macrophages

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The immune system plays a pivotal role in bone regeneration, and biomaterials engineered to modulate immune responses present a promising strategy for the treatment of extensive bone defects and osteolytic conditions. This review critically evaluates recent advancements in immunomodulatory biomaterials for bone repair, integrating perspectives from both immunology and materials science. It offers a comprehensive analysis of key design strategies and the underlying principles guiding the development of these biomaterials, with a particular focus on their physical and chemical properties, bioactive molecule delivery systems, cell transplantation techniques, and responses to external stimuli. Additionally, this review examines the interactions between these biomaterials and immune cells, particularly macrophages, within various pathological contexts. Finally, the paper discusses current challenges and future directions, aiming to provide researchers and clinicians with a valuable resource for advancing this rapidly evolving field.© 2025 The Author(s). Advanced Science published by Wiley‐VCH GmbH.

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大类 | 1 区

综合性期刊

小类 | 1 区化学：综合 1 区材料科学：综合 1 区纳米科技

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大类 | 1 区

综合性期刊

小类 | 1 区化学：综合 1 区材料科学：综合 1 区纳米科技

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第一作者机构： [1]Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.

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