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Hierarchical assembly of nanostructured coating for siRNA-based dual therapy of bone regeneration and revascularization.

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收录情况： ◇ SCIE ◇ EI

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机构： [1]Department of Prosthodontics, Beijing Stomatological Hospital and School of Stomatology, Capital Medical University, Beijing, 100050, China [2]Hospital of Stomatology, Shanxi Medical University, Taiyuan, 030001, China [3]School of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China [4]Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, 02115, United States [5]ARC Centre of Excellence in Convergent Bio-Nano Science and Technology and Department of Chemical and Biomolecular Engineering, The University of Melbourne,Parkville, Victoria, 3010, Australia [6]Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, P. O. Box 16300, 00076, Finland [7]Department of Pathology, Brigham and Women's Hospital, Harvard University, Boston, MA, 02115, United States [8]Department of Removable Prosthodontics and Occlusion, Osaka Dental University, Hirakata, Osaka, 540-8570, Japan [9]The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, School of Basic Medicine, The Fourth Military Medical University, Xi'an,710032, China

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关键词： Colloidal assembly Surface functionalization siRNA Revascularization Bone regeneration

摘要：

Advancing bone implant engineering offers the opportunity to overcome crucial medical challenges and improve clinical outcomes. Although the establishment of a functional vascular network is crucial for bone development, its regeneration inside bone tissue has only received limited attention to date. Herein, we utilize siRNA-decorated particles to engineer a hierarchical nanostructured coating on clinically used titanium implants for the synergistic regeneration of skeletal and vascular tissues. Specifically, an siRNA was designed to target the regulation of cathepsin K and conjugated on nanoparticles. The functionalized nanoparticles were assembled onto the bone implant to form a hierarchical nanostructured coating. By regulating mRNA transcription, the coating significantly promotes cell viability and growth factor release related to vascularization. Moreover, microchip-based experiments demonstrate that the nanostructured coating facilitates macrophage-induced synergy in up-regulation of at least seven bone and vascular growth factors. Ovariectomized rat and comprehensive beagle dog models highlight that this siRNA-integrated nanostructured coating possesses all the key traits of a clinically promising candidate to address the myriad of challenges associated with bone regeneration. Copyright © 2020 Elsevier Ltd. All rights reserved.

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出版当年[2020]版：

大类 | 1 区

工程技术

小类 | 1 区工程：生物医学 1 区材料科学：生物材料

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区工程：生物医学 1 区材料科学：生物材料

JCR分区：

出版当年[2020]版：

Q1 MATERIALS SCIENCE, BIOMATERIALS Q1 ENGINEERING, BIOMEDICAL

最新[2023]版：

Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 12.8 最新[2023版] 13.1 最新五年平均 12.479 出版当年[2020版] 12.104 出版当年五年平均 10.317 出版前一年[2019版] 15.304 出版后一年[2021版]

第一作者：

第一作者机构： [1]Department of Prosthodontics, Beijing Stomatological Hospital and School of Stomatology, Capital Medical University, Beijing, 100050, China

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通讯作者：

通讯机构： [3]School of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China [4]Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, 02115, United States [*1]School of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China

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Hierarchical assembly of nanostructured coating for siRNA-based dual therapy of bone regeneration and revascularization.

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