机构：[1]Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou510080, China.广东省人民医院[2]School of Health Science and Biomedical Engineering, Hebei University of Technology, Tianjin300130, China.[3]School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300130, China.[4]State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai200050, China.[5]State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu610041, China.
Bone implants with the photothermal effect are promising for the treatment of bone tumor defects. Noble metal-based photothermal nanoagents are widely studied for their stable photothermal effect, but they are expensive and difficult to directly grow on implant surfaces. In contrast, non-noble metal photothermal nanoagents are economical but unstable. Herein, to develop a stable and economical photothermal film on bone implants, a Ni nanoparticle-doped oxide semiconductor film was grown in situ on Nitinol via the reduction of Ni-Ti-layered double hydroxides. Ni nanoparticles remained stable in the NiTiO3 structure even when immersed in fluid for 1 month, and thus, the film presented a reliable photothermal effect under near-infrared light irradiation. The film also showed excellent in vitro and in vivo antitumor performance. Moreover, the nanostructure on the film allowed bone differentiation of mouse embryo cells (C3H10T1/2), and the released Ni ions supported the angiogenesis behavior of human vein endothelial cells. Bone implantation experiments further showed the enhancement of osteointegration of the modified Nitinol implant in vivo. This novel multifunctional Nitinol bone implant design offers a promising strategy for the therapy of bone tumor-related defects.
基金：
National Natural Science Foundation of China (52001076
and 51901239), Science and Technology Commission of
Shanghai Municipality (19JC1415500), Natural Science
Foundation of Hebei Province of China (E2021202001 and
E2020202028), and GDPH Supporting Fund for Talent
Program (KY0120220137 and KY012021462).
第一作者机构：[1]Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou510080, China.
共同第一作者：
通讯作者：
通讯机构：[1]Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou510080, China.[2]School of Health Science and Biomedical Engineering, Hebei University of Technology, Tianjin300130, China.[*1]School of Health Science and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China[*2]Medical Research Center, Department of Orthopedics, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
推荐引用方式(GB/T 7714)：
Yao Mengyu,Hao Xueqin,Shao Hongwei,et al.Metallic Nanoparticle-Doped Oxide Semiconductor Film for Bone Tumor Suppression and Bone Regeneration[J].ACS APPLIED MATERIALS & INTERFACES.2022,14(42):47369-47384.doi:10.1021/acsami.2c10672.
APA：
Yao Mengyu,Hao Xueqin,Shao Hongwei,Wang Donghui,Li Baoe...&Peng Feng.(2022).Metallic Nanoparticle-Doped Oxide Semiconductor Film for Bone Tumor Suppression and Bone Regeneration.ACS APPLIED MATERIALS & INTERFACES,14,(42)
MLA：
Yao Mengyu,et al."Metallic Nanoparticle-Doped Oxide Semiconductor Film for Bone Tumor Suppression and Bone Regeneration".ACS APPLIED MATERIALS & INTERFACES 14..42(2022):47369-47384
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