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Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ ESCI

作者：
Zhao Tian[1] * ; Huang Ye[1] ; Zhu Jingfei[1] ; Qin Yujie[1] ; Wu Hao[2] ; Yu Jiaxuan[1] ; Zhai Qianwen[1,3] ; Li Shun[1] ; Qin Xiang[1] ; Wang Dengfeng[1] ; Li Tingting[1] ; Liu Yiyao[1,2,4] ;
机构： [1]Department of Gynecologic Oncology Sichuan Clinical Research Center for Cancer Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, and School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu P. R. China. [2]TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese Medicine Chengdu P. R. China. [3]Department of Clinical Medicine North Sichuan Medical College Nanchong P.R. China. [4]Department of Urology Deyang People's Hospital Deyang P. R. China.
出处：
DOI： 10.1002/mco2.70281

关键词： ECM dysregulation ECM remodeling ECM targeted therapies extracellular matrix (ECM) mechanotransduction

摘要：
Extracellular matrix (ECM) is a dynamic, three-dimensional network that provides structural support and regulates key biological processes, including cell adhesion, migration, differentiation, and signal transduction. Its mechanical properties, such as stiffness, topology, and viscoelasticity, are crucial in normal and pathological conditions, influencing cell behavior through mechanotransduction pathways. Dysregulation of ECM is linked to various diseases, making a thorough understanding of its composition and properties essential. This review discusses ECM composition, physical properties, and the limitations of in vitro ECM models. It highlights the role of ECM in tissue homeostasis, particularly in regulating cell behavior via mechanotransduction, focusing on force-sensitive sensors like integrins, Piezo1, TRPV4, and YAP/TAZ. Additionally, the review explores ECM remodeling in cancer, fibrosis, and cardiovascular diseases, along with current therapeutic strategies targeting ECM components, such as nanotechnology-based therapies, small molecule inhibitors, and CAF-targeted therapies. Challenges and clinical applications of these therapies are also discussed. Finally, the review looks ahead to future research, emphasizing the integration of ECM-targeted therapies in precision medicine and novel approaches to normalizing ECM composition and structure for therapeutic benefits. This review provides mechanobiological insights into therapeutic strategies targeting the ECM.© 2025 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

基金：
the National Natural Science Foundation of China (32471364, 32171309, 12132004, 32471367,12472318, 12272086), the Program for Innovative Fundamental Research Incubation of UESTC (Y03023206100226), and the Joint Innovation Fund of Health Commission of Chengdu and Chengdu University of Traditional Chinese Medicine (WXLH202403090).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 1 区 医学
小类 | 1 区 医学：研究与实验
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 医学：研究与实验
JCR分区：
出版当年[2024]版：
Q1 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2024]版：
Q1 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 最新[2024版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2024版]

第一作者：
第一作者机构： [1]Department of Gynecologic Oncology Sichuan Clinical Research Center for Cancer Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, and School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu P. R. China.
通讯作者：
通讯机构： [1]Department of Gynecologic Oncology Sichuan Clinical Research Center for Cancer Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, and School of Life Science and Technology, University of Electronic Science and Technology of China Chengdu P. R. China. [2]TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese Medicine Chengdu P. R. China. [4]Department of Urology Deyang People's Hospital Deyang P. R. China.
推荐引用方式(GB/T 7714)：
Zhao Tian,Huang Ye,Zhu Jingfei,et al.Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets[J].Medcomm.2025,6(8):e70281.doi:10.1002/mco2.70281.
APA：
Zhao Tian,Huang Ye,Zhu Jingfei,Qin Yujie,Wu Hao...&Liu Yiyao.(2025).Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets.Medcomm,6,(8)
MLA：
Zhao Tian,et al."Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets".Medcomm 6..8(2025):e70281

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