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Inflammatory Bowel Disease Induces Colorectal Cancer: Risk Factors, Triggering Mechanisms, and Treatment With Phyto-Derivatives

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机构: [1]College of Food and Bioengineering, Xihua University, Chengdu, China. [2]Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. [3]College of Comprehensive Health Management, Xihua University, Chengdu, China. [4]Institute of Molecular Medicine (IMM), Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
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关键词: colitis colitis-associated cancer gut microbiota inflammatory bowel disease natural products

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Colorectal cancer (CRC), one of the most prevalent malignant neoplasms, ranks as a leading cause of cancer-related mortality on a global scale. A particularly aggressive variant of CRC is colitis-associated colon cancer (CAC). Patients with chronic inflammatory bowel disease (IBD) are at increased risk for CAC. The pathogenesis of CAC is influenced by numerous factors and is highly complex. Due to the complexity of the mechanism by which chronic inflammation of the intestine leads to the transformation of colorectal cancer, there is currently no standardized strategy for the advance prophylaxis of CAC. Significantly, phyto-derivatives exhibit significant potential in the prevention of CAC. Currently, researches have demonstrated that natural products extracted from plants including polyphenols, alkaloids, saponins, terpenoids, polysaccharides, and plant extracellular vesicles can achieve significant anti-inflammatory, antioxidant, and gut microbiota regulating activities through oral administration. It is a valuable opportunity for the application of natural products in chronic intestinal inflammation to inhibit the transformation of intestinal inflammation into malignancy. In this review, we provide a comprehensive analysis of the predisposing factors and pathogenesis of CAC, along with the mechanisms through which various plant-derived compounds inhibit CAC development. This work aims to provide innovative and practical treatment strategies for the prevention of CAC.© 2025 John Wiley & Sons Ltd.

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出版当年[2025]版:
大类 | 2 区 医学
小类 | 2 区 药物化学 2 区 药学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 药物化学 2 区 药学
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第一作者机构: [1]College of Food and Bioengineering, Xihua University, Chengdu, China.
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