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Lymphatic-immune interactions in the musculoskeletal system

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机构： [1]Tissue and Tumor Microenvironments Lab, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. [2]State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China. [3]State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. [4]University of Coimbra, Multidisciplinary Institute of Ageing (MIA-Portugal), Coimbra, Portugal.

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关键词： lymphatics immune bone aging musculoskeletal

摘要：

Traditionally, the role of lymphatic vessels has been understood as primarily involving fluid transport and immune surveillance. In addition to these roles, recent studies have revealed a paracrine function of lymphatics through the dissemination of inductive factors, known as lymphangiocrine signals including in musculoskeletal physiology and diseases. These signals play diverse roles, including maintaining tissue equilibrium and facilitating regeneration. Impaired lymphangiocrine signaling and lymphatic function are features of musculoskeletal diseases. This review summarizes dysregulation of lymphatic vessels and interactions with immune cells during musculoskeletal diseases. Further, this review provides insights into lymphangiocrine signals as a potential therapeutic target.Copyright © 2025 Liu, Liu, Zhang, Tian, Ding, Chen and Kusumbe.

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出版当年[2025]版：

大类 | 2 区医学

小类 | 2 区免疫学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区免疫学

第一作者：

第一作者机构： [1]Tissue and Tumor Microenvironments Lab, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

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通讯作者：

通讯机构： [1]Tissue and Tumor Microenvironments Lab, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. [4]University of Coimbra, Multidisciplinary Institute of Ageing (MIA-Portugal), Coimbra, Portugal.

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