机构：[1]International Institute of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China.[2]Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou 215123, China.[3]Department of Laboratory Medicine, Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China.四川省人民医院
Innate immunity is an important component of the immune system and serves as the first line of defense for the host against the invasion of foreign pathogens. Viperin (RSAD2), a core member of the interferon-stimulated gene (ISG) family, plays a key role in innate immunity through direct inhibition of viral replication and modulation of the host immune-metabolic network. The intracellular expression of Viperin rises markedly after viral infection or interferon-induced induction, showing a wide range of antiviral activities. In recent years, the versatility of Viperin in viral infections, autoimmune diseases, and tumor immune metabolism has been gradually revealed. Here, we summarize and discuss the gene regulatory network, molecular functions, and multi-dimensional roles of Viperin in diseases to provide a theoretical basis for the development of broad-spectrum antiviral strategies and immunometabolic therapies based on Viperin.
基金：
This work is supported by grants from The National Natural Science Foundation of China
(32241009), the Sichuan Science and Technology Program (2025ZNSFSC1095), the Suzhou Medical
College Basic Frontier lnnovation Cross Research Project (YXY2304060), the China Postdoctoral
Science Foundation (2024M750364), and the Priority Academic Program Development of Jiangsu
Higher Education Institutions (PAPD).
第一作者机构：[1]International Institute of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China.[2]Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou 215123, China.
通讯作者：
通讯机构：[1]International Institute of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China.[2]Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou 215123, China.[3]Department of Laboratory Medicine, Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China.
推荐引用方式(GB/T 7714)：
Cui Qun,Miao Ying,Li Min,et al.Viperin: A Multifunctional Protein in Antiviral Immunity and Disease Pathogenesis[J].Pathogens (Basel, Switzerland).2025,14(5):doi:10.3390/pathogens14050510.
APA：
Cui Qun,Miao Ying,Li Min,Zheng Hui&Yuan Yukang.(2025).Viperin: A Multifunctional Protein in Antiviral Immunity and Disease Pathogenesis.Pathogens (Basel, Switzerland),14,(5)
MLA：
Cui Qun,et al."Viperin: A Multifunctional Protein in Antiviral Immunity and Disease Pathogenesis".Pathogens (Basel, Switzerland) 14..5(2025)
