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The Role of Vitamin D in Gastrointestinal Diseases: Inflammation, Gastric Cancer, and Colorectal Cancer.

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Chen Yao[1,2,3] ; Hou Jue[4] ; Xiao Zhangang[1,2,3] ; Zhao Yueshui[1,2,3] ; Du Fukuan[1,2,3] ; Wu Xu[1,2,3] ; Li Mingxing[1,2,3] ; Chen Yu[1,2] ; Zhang Lin[5,6,7] ; Cho Chi Hin[1,2,3] ; Wen Qinglian[4,*1] ; Hu Wei[8,*2] ; Shen Jing[1,2,3,*3] ;
机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, P.R. China. [2]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan, P.R. China. [3]Laboratory of Personalised Cell Therapy and Cell medicines, School of Pharmacy, Southwest Medical University, Luzhou 646000, P.R. China. [4]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan646000, P.R. China. [5]Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China. [6]Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Science, Chinese University of Hong Kong, Shatin, Hong Kong, P.R. China. [7]Department of Anaesthesia and Intensive Care and Peter Hung Pain Research Institute, The Chinese University of Hong Kong, Hong Kong, P.R. China. [8]Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, P.R. China.
出处：
DOI： 10.2174/0929867328666211111163304
ISSN：

关键词： Vitamin D metabolism innate immunity antimicrobial peptide inflammation gastrointestinal cancer

摘要：
Vitamin D as a prohormone is converted into the active form in vivo and binds to vitamin D receptors, exercising a wide range of biological functions. Recent studies strongly support that vitamin D supplementation is associated with reduced cancer risk and a good prognosis. Gastrointestinal cancer is the leading cause of cancer-related deaths worldwide. The key role of vitamin D in the development of gastrointestinal cancer has been observed. Moreover, Vitamin D can also affect innate immunity and perform anti-inflammation and anti-infection actions. Given the intimate relationship between cancer and inflammation, we herein summarize epidemiological and preclinical studies of vitamin D and the underlying mechanism of its action in inflammation, gastric and colorectal cancer by our group and other researchers. A beneficial effect of vitamin D in cancer and inflammatory disease has been supported by different studies. More controlled and larger clinical trials are needed before a reliable conclusion and realization of vitamin D supplementation in the adjunct treatment of gastrointestinal inflammation and cancer.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

基金：
National Natural Science Foundation of China (No. 81974070, 81972643 & 81800503), National Key R&D Project of China (No. 2018YFC0115301), Guangdong Basic and Applied Basic Research Foundation (2020A151 5011063), Sichuan Science and Technology Project (2021YJ0201).
语种：
外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 2 区 药物化学 3 区 生化与分子生物学 3 区 药学
最新[2023]版：
大类 | 4 区 医学
小类 | 3 区 生化与分子生物学 3 区 药物化学 3 区 药学
JCR分区：
出版当年[2022]版：
Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CHEMISTRY, MEDICINAL Q2 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 CHEMISTRY, MEDICINAL Q2 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, P.R. China. [2]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan, P.R. China. [3]Laboratory of Personalised Cell Therapy and Cell medicines, School of Pharmacy, Southwest Medical University, Luzhou 646000, P.R. China.
共同第一作者：
通讯作者：
通讯机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, P.R. China. [2]South Sichuan Institute of Translational Medicine, Luzhou, Sichuan, P.R. China. [3]Laboratory of Personalised Cell Therapy and Cell medicines, School of Pharmacy, Southwest Medical University, Luzhou 646000, P.R. China. [4]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan646000, P.R. China. [8]Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, P.R. China. [*1]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China [*2]Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China [*3]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China
推荐引用方式(GB/T 7714)：
Chen Yao,Hou Jue,Xiao Zhangang,et al.The Role of Vitamin D in Gastrointestinal Diseases: Inflammation, Gastric Cancer, and Colorectal Cancer.[J].CURRENT MEDICINAL CHEMISTRY.2022,29(22):3836-3856.doi:10.2174/0929867328666211111163304.
APA：
Chen Yao,Hou Jue,Xiao Zhangang,Zhao Yueshui,Du Fukuan...&Shen Jing.(2022).The Role of Vitamin D in Gastrointestinal Diseases: Inflammation, Gastric Cancer, and Colorectal Cancer..CURRENT MEDICINAL CHEMISTRY,29,(22)
MLA：
Chen Yao,et al."The Role of Vitamin D in Gastrointestinal Diseases: Inflammation, Gastric Cancer, and Colorectal Cancer.".CURRENT MEDICINAL CHEMISTRY 29..22(2022):3836-3856

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